{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:01:53Z","timestamp":1778169713118,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>A number of studies have linked obesity with asthma in adults and children. Few longitudinal studies have evaluated the effect of maternal pre-pregnancy obesity on either asthma or early childhood respiratory morbidity, and these have not been in urban, nonwhite populations. We sought to determine whether pre-pregnancy obesity was associated with recurrent wheezing in an urban, nonwhite population. This study includes 1,191 children from the Boston Birth Cohort (1998\u2013present) followed prospectively to a mean age of 3.0\u2009\u00b1\u20092.4 years with study visits aligned with the pediatric primary care schedule. Multivariate logistic regression was used to evaluate the associations of maternal pre-pregnancy obesity (body mass index \u226530) with recurrent wheezing (\u22654 lifetime episodes). Secondary outcomes included log-transformed cord-blood immunoglobulin E (Phadia), and physician diagnoses of eczema and food allergy. Pre-pregnancy obesity was present in 20.7% of mothers. Of the 1,191 children, 60 (5%) developed recurrent wheezing. Children of obese mothers had an increased risk of recurrent wheezing (adjusted odds ratio, 95% confidence interval: 3.51, 1.68\u20137.32). These associations persisted even after adjustment for fetal growth status. In contrast, maternal obesity was not associated with eczema or food allergy, and was inversely associated with log cord-blood immunoglobulin E (\u03b2, 95% confidence interval: \u22120.34, \u22120.66 to \u22120.02). In this predominantly urban, multiracial\/ethnic birth cohort, maternal pre-pregnancy obesity was associated with an increased risk of recurrent wheezing. This association was not explained by fetal growth or increased atopy. Maternal pre-pregnancy obesity is a prevalent risk factor for respiratory morbidity in this urban, nonwhite population.<\/jats:p>","DOI":"10.1089\/ped.2010.0032","type":"journal-article","created":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T05:06:26Z","timestamp":1286773586000},"page":"183-190","source":"Crossref","is-referenced-by-count":44,"title":["Maternal Pre-Pregnancy Obesity and Recurrent Wheezing in Early Childhood"],"prefix":"10.1177","volume":"23","author":[{"given":"Rajesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Children's Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Story","sequence":"additional","affiliation":[{"name":"Children's Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Pongracic","sequence":"additional","affiliation":[{"name":"Children's Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Hong","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester","family":"Arguelles","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Kuptsova-Clarkson","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Pearson","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Bonzagni","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Apollon","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Fu","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Bauchner","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Memorial Research Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-008-0388-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.050"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.194"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-007-0292-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2009.01034.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.2.131"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.1.31"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00008406"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.011"},{"key":"e_1_3_3_11_2","first-page":"740","article-title":"Differences in prevalence of obesity among black, white, and Hispanic adults\u2014United States, 2006\u20132008","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","unstructured":"Centers for Disease Control and Prevention. 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