{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:59:27Z","timestamp":1777928367783,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Dedicator of cytokinesis 8 (\n                    <jats:italic toggle=\"yes\">DOCK8<\/jats:italic>\n                    ) deficiency is a rare and recently described immunodeficiency, which is characterized with cutaneous viral and sinopulmonary infections, eczema, and high IgE levels. A\n                    <jats:italic toggle=\"yes\">DOCK8<\/jats:italic>\n                    deficient patient who had been followed up for severe atopic dermatitis, multiple food allergies, and asthma for several years is reported and clues are given for the diagnosis of\n                    <jats:italic toggle=\"yes\">DOCK8<\/jats:italic>\n                    deficiency. A 7-year-old girl was referred due to refractory eosinophilia and eczema. She had angioedema of the lips and increase in eczematous lesions during infancy after milk and egg ingestion and during childhood after fish, hazelnut, and wheat-containing food ingestion. She had episodic wheezing attacks since she was 1-year-old, and she had recurrent pneumonia and acute otitis media in the following years. She was hospitalized for pyoderma after a zona zoster infection. Laboratory findings suggested\n                    <jats:italic toggle=\"yes\">DOCK8<\/jats:italic>\n                    deficiency and mutational analysis verified. She had stem cell transplantation from a matched unrelated donor but unfortunately she died due to pneumonia 3 months after transplantation. Even though infants have food allergy and recurrent wheezing attacks, the presence of refractory eczema should be carefully followed up by pediatricians for the presence of recurrent cutaneous infections to exclude the diagnosis of\n                    <jats:italic toggle=\"yes\">DOCK8<\/jats:italic>\n                    deficiency in which stem cell transplantation is the only option and must be done as soon as possible.\n                  <\/jats:p>","DOI":"10.1089\/ped.2012.0179","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T11:18:21Z","timestamp":1352891901000},"page":"48-51","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of\n                    <i>DOCK8<\/i>\n                    Deficient Hyper-IgE Syndrome Presenting Primarily With Eczema, Food Allergy, and Asthma"],"prefix":"10.1177","volume":"26","author":[{"given":"Ozlem","family":"Cavkaytar","sequence":"first","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Cagdas Ayvaz","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Keskin","sequence":"additional","affiliation":[{"name":"Gaziantep University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Arik Yilmaz","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Buyuktiryaki","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit Murat","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman Tolga","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayfer","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansin","family":"Sackesen","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozden","family":"Sanal","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905506"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.038"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834c7f65"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/972591"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8252-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.020"},{"key":"e_1_3_3_9_2","first-page":"321","article-title":"Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer","volume":"28","author":"Takahashi K","year":"2006","unstructured":"Takahashi K, , Kohno T, , Ajima R, , Sasaki H, , Minna JD, , Fujiwara T, , Tanaka N, , Yokota J. 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Asian Pac J Cancer Prev, 2009; 10:501\u2013506.","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_3_3_11_2","first-page":"327","article-title":"Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung","volume":"37","author":"Kang JU","year":"2010","unstructured":"Kang JU, , Koo SH, , Kwon KC, , Park JW. Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung. 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