{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:59:40Z","timestamp":1777928380917,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    This study has investigated a potential role of common Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene variants in the etiology of noncystic fibrosis bronchiectasis in Serbian children. The study has encompassed 48 patients (19 male and 29 female, aged between 5 and 18 years, median age 10.6\u00b13.3), diagnosed with idiopathic bronchiectasis based on high-resolution computed tomography of thorax and pathologic examination of lobectomy materials. The CFTR gene analysis was performed on genomic DNA extracted from peripheral blood samples of patients by polymerase chain reaction (PCR)-Mediated Site-Directed Mutagenesis method, Denaturing Gradient Gel Electrophoresis method, and DNA sequencing. Mutation c.1521_1523delCTT (F508del) was detected with an allelic frequency of 1.0%, and c.224G&gt;A (R75Q) variant. Carriers of c.1210-12T[5] (IVS8-5T) allele were significantly more common than in the general population (10.4% vs. 5.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.0302). The frequency of homozygotes for Met 470 allele was higher in patients than in the general population (33% vs. 20%), while heterozygotes for p.Met470Val were less frequent (31% vs. 50%), and this difference was statistically significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.0222). The results obtained in this study indicate involvement of 2 common CFTR variants, c.1210-12T[5] and c.1408A, in idiopathic bronchiectasis in children, but this observation should be further confirmed by more extensive analysis of the CFTR gene in a larger group of patients.\n                  <\/jats:p>","DOI":"10.1089\/ped.2013.0238","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T14:09:30Z","timestamp":1365257370000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of CFTR Gene Variants in Idiopathic Bronchiectasis in Serbian Children"],"prefix":"10.1177","volume":"26","author":[{"given":"Katarina","family":"Milosevic","sequence":"first","affiliation":[{"name":"University Children's Hospital","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Nikolic","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Divac Rankov","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mila","family":"Ljujic","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branimir","family":"Nestorovic","sequence":"additional","affiliation":[{"name":"University Children's Hospital","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica","family":"Radojkovic","sequence":"additional","affiliation":[{"name":"University of Belgrade","place":["Serbia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10104"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.4.1063"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029497"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.2003.00028.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-006-0861-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S215"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39028"},{"key":"e_1_3_3_9_2","first-page":"889","article-title":"CFTR gene variant IVS8-5T in disseminated bronchiectasis","volume":"58","author":"Pignatti PF","year":"1996","unstructured":"Pignatti PF, , Bombieri C, , Benetazzo M, , Casartelli A, , Trabetti E, , Gile LS, , Martinati LC, , Boner AL, , Luisetti M. 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