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Pediatric mastocytosis is due to the effects of mast-cell degranulation enzymes such as histamine and tryptase causing the presentation of pruritis, flushing, vesicles, abdominal and bone pain, or headache. Three different forms of mastocytosis can occur: urticaria pigmentosa, diffuse cutaneous, and solitary mastocytoma. Systemic symptoms are typically a result of mast-cell mediator release but do not prove systemic mast-cell hyperplasia. In this review, we present several research studies related to pediatric mast-cell disorders, and discuss several cases of pediatric mastocytosis, acute myeloid leukemia, pathophysiology, genetic studies, and treatment.<\/jats:p>","DOI":"10.1089\/ped.2013.0275","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T11:50:51Z","timestamp":1387194651000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Pediatric Mastocytosis: A Review of the Literature"],"prefix":"10.1177","volume":"26","author":[{"given":"Marianne","family":"Frieri","sequence":"first","affiliation":[{"name":"Nassau University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahvish","family":"Quershi","sequence":"additional","affiliation":[{"name":"Nassau University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12468942"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469034"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854189778968551"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01166.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03005.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.29534"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02812.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31817e6d7c"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.291"},{"key":"e_1_3_2_11_2","first-page":"214","article-title":"C-kit asp-816-val mutation analysis in patients with mastocytosis","author":"Verzijl A","year":"2007","unstructured":"Verzijl A, , Heide R, , Oranje AP, , van Schaik RH. 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