{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:55Z","timestamp":1777928455438,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>The treatment of severe combined immunodeficiency (SCID) is immune reconstitution using hematopoietic stem cell (HSC) transplantation early in life. HLA-identical related donors are the preferred source of HSCs. Since sibling donors are available in &lt;30% of patients, other sources of HSCs are considered\u2014mismatched related donor, umbilical cord blood (UCB), and matched unrelated donor bone marrow. We report the outcome of 10 patients with SCID or combined immunodeficiency (CID) 10 years after UCB transplantation (UCBT) at our institution using a retrospective chart review. Eight patients were alive 10 years post-transplantation. This was the second transplant for 2 patients due to initial transplant engraftment failure. Immunologic reconstitution was demonstrated after transplant with presence of memory T cells at 3 months, naive T cells at 12 months, B cells at 3 months, and normal tetanus\/diphtheria toxoid antibody responses at 2 years. Immune response remained robust 10 years post-transplantation. Eight patients developed stage I acute graft-versus-host disease (GvHD), 2 patients developed grades 2\u20144 GvHD, and 1 child developed chronic GvHD with bronchiolitis obliterans. UCB should be considered as an alternative HSC source for patients with SCID and CID because of its robust and sustained recovery of immune function, low risk of severe GvHD, and accessibility.<\/jats:p>","DOI":"10.1089\/ped.2017.0785","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:34:15Z","timestamp":1533861255000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes for Umbilical Cord Blood Transplantation in Severe Combined Immunodeficiency Disorders: Ten-Year Experience"],"prefix":"10.1177","volume":"30","author":[{"given":"Carrie","family":"Caruthers","sequence":"first","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermina","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Shams","sequence":"additional","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P.","family":"Knutsen","sequence":"additional","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Bhatla","sequence":"additional","affiliation":[{"name":"Saint Louis University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9132"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.043"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.11.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-363572"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.11.619"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026463900925"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-453175"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702728"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104614"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902183400703"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.07.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401177"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.015"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.035"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","unstructured":"Antin JH Raley DY. 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