{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:01:20Z","timestamp":1777928480391,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Severe postinfectious diffuse pulmonary disease may clinically mimic other entities of children's interstitial lung disease and is clinically challenging comprising various disease severities despite treatment. Long-term lung function trend and physical capacity in children with postinfectious diffuse pulmonary disease are rarely reported. We investigated trends in pulmonary function by long-term follow-up and assessed physical capacity in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We performed a descriptive, single-center follow-up study in children with biopsy-verified postinfectious diffuse pulmonary disease. Patients with completed primary treatment course were eligible for follow-up, including pulmonary function and exercise (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty patients with postinfectious diffuse pulmonary disease were identified and included. Median (range) age at diagnose was 27.5 (2\u2013172) months after a mean lag time of 23 months.\n                      <jats:italic toggle=\"yes\">H. influenzae<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">rhinovirus<\/jats:italic>\n                      were the most frequent pathogens. Fifteen patients were available for follow-up after mean (range) 7.6 (2\u201315) years of treatment completion. Lung clearance index (LCI\n                      <jats:sub>2.5<\/jats:sub>\n                      ), forced expiratory volume in 1\u2009second (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), and bronchodilator responsiveness were abnormal in 80%, 53%, and 44%, respectively. Diffusion capacity for monoxide was abnormal in 7% and total lung capacity in 33%. Only 8% demonstrated low VO\n                      <jats:sub>2peak<\/jats:sub>\n                      , while 40% reported difficulties during physical exertion. Longitudinal data on spirometry (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914) remained unchanged from end of treatment throughout follow-up. A significant association was found between zLCI\n                      <jats:sub>2.5<\/jats:sub>\n                      and zFEV\n                      <jats:sub>1<\/jats:sub>\n                      (multiple linear regression;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.61;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.0003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Postinfectious diffuse pulmonary disease in children carries a varying degree of chronic pulmonary impairment with onset of symptoms in the first months of life and a typical considerable lag time before diagnosis. Follow-up several years after the initial injury demonstrated moderate-to-severe peripheral airway impairment although no further lung function decline was found years after completion of treatment. Despite acceptable VO\n                      <jats:sub>2peak<\/jats:sub>\n                      , a considerable proportion struggled during heavy exercise.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2018.0973","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T16:30:55Z","timestamp":1553099455000},"page":"4-11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Lung Function and Exercise Capacity in Postinfectious chILD"],"prefix":"10.1177","volume":"32","author":[{"given":"Yagmur","family":"Sisman","sequence":"first","affiliation":[{"name":"Danish chILD Centre, Paediatric Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik F.","family":"Buchvald","sequence":"additional","affiliation":[{"name":"Danish chILD Centre, Paediatric Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid Madsen","family":"Ring","sequence":"additional","affiliation":[{"name":"Danish chILD Centre, Paediatric Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Wassilew","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Gjerum","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Danish chILD Centre, Paediatric Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.07.005"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282ff62e9"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.052670"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20145"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-199904000-00003"},{"key":"e_1_3_4_7_2","first-page":"187","article-title":"Post-infectious bronchiolitis obliterans in children","volume":"87","author":"Champs NS","year":"2011","unstructured":"Champs NS, , Lasmar LM, , Camargos PA, et al. 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