{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:23:52Z","timestamp":1782757432765,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Impaired lung function has been detected in up to 65% of all childhood cancer survivors. It is often caused by exposure to radiation therapy and various chemotherapeutics. The first cytotoxic drug ever identified as a causative agent of lung injury was busulfan, reported in the early 1960s. Signs and symptoms of busulfan lung are nonspecific and it is therefore difficult to differentiate the condition from pulmonary impairment caused by other pulmotoxic agents, infections, pulmonary metastases, graft-versus-host disease, or other noninfectious post-transplant complications involving the lungs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A case example is provided to illustrate the difficulties in management of busulfan-induced lung injury in children. A retrospective review of cases of busulfan-induced lung injury indexed in PubMed until March 2019 was performed. Inclusion criteria for articles was available in full text in English.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Impaired lung function caused by busulfan may become an increasing problem for young survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Newly developed dyspnea or subclinical damage detected on pulmonary function tests, indicating primarily restrictive disease, should always arouse suspicion of busulfan-induced lung injury in a child conditioned with busulfan, especially after excluding other leading culprits of pulmonary damage affecting oncology patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2019.0990","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T12:34:26Z","timestamp":1568896466000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Busulfan-Induced Lung Injury in Pediatric Oncology Patients\u2014Review of the Literature with an Illustrative Case"],"prefix":"10.1177","volume":"32","author":[{"given":"Nusa","family":"Matijasic","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital Zagreb, Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Bonevski","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital Zagreb, Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visnja","family":"Tokic Pivac","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children's Hospital Zagreb, Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Pavic","sequence":"additional","affiliation":[{"name":"Departments of Pulmonology, Allergology, Immunology, and Rheumatology, Children's Hospital Zagreb, Zagreb, Croatia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Howlader N Noone AM Krapcho M Miller D Bishop K Kosary CL Yu M Ruhl J Tatalovich Z Mariotto A Lewis DR Chen HS Feuer EJ Cronin KA (eds). SEER Cancer Statistics Review 1975\u20132014 National Cancer Institute. Bethesda MD https:\/\/seer.cancer.gov\/csr\/1975_2014\/ based on November 2016 SEER data submission posted to the SEER web site April 2017."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320130053028"},{"key":"e_1_3_2_4_2","first-page":"217","article-title":"Cytotoxic drug-induced lung injury","volume":"3","author":"Snyder LS","year":"1988","unstructured":"Snyder LS, , Hertz MI. Cytotoxic drug-induced lung injury. 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