{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:01:36Z","timestamp":1777928496663,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    Nasal polyps are a concern for both adults and children. The treatment of nasal polyps typically is glucocorticoids, both topically and systemically administered. However, patients often experience refractory nasal polyps. A proposed reason for unsatisfactory treatment for the reoccurrence of nasal polyps is because of the drug delivery options through the nose that requires patients to coordinate actuation, head placement, and administration. In addition, many of these delivery systems have shown poor delivery efficiency due to medication depositing into the lungs. To combat these difficulties, Optinose has created an exhalation delivery system that could be used for both liquid and powered medications. Xhance\n                    <jats:sup>\u00ae<\/jats:sup>\n                    (fluticasone propionate), which uses this new delivery system, is currently approved for the treatment of nasal polyps in adults. It has shown promising results in adults and is currently undergoing evaluation in pediatric patients.\n                  <\/jats:p>","DOI":"10.1089\/ped.2019.1066","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T12:34:26Z","timestamp":1568896466000},"page":"128-130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Exhalation Delivery System: Novel Device for Nasal Polyps Treatment"],"prefix":"10.1177","volume":"32","author":[{"given":"Rebecca","family":"Chu","sequence":"first","affiliation":[{"name":"NYU Winthrop, Mineola, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"S77","article-title":"Nasal polyposis in children","volume":"261","author":"Caimmi D","year":"2012","unstructured":"Caimmi D, , Matti E, , Pelizzo G, et al. Nasal polyposis in children. 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The \u2018best method\u2019 of topical nasal drug delivery: comparison of seven techniques. Rhinology, 2006; 44:102\u2013107.","journal-title":"Rhinology"},{"key":"e_1_3_3_14_2","unstructured":"XHANCE\u00ae (fluticasone propionate) [package insert]. Yardley PA: OptiNose US Inc. 2019 p. 7."},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","unstructured":"Palmer JN Jacobson KW Messina JC et al. EXHANCE-12: 1-year study of the exhalation delivery system with fluticasone (EDS-FLU) in chronic rhinosinusitis. Int Forum Allergy Rhinol 2018. [Epub ahead of print]; DOI: 10.1002\/alr.22141","DOI":"10.1002\/alr.22141"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","unstructured":"Djupesland PG Skretting A. Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pump. J Aerosol Med Pulm 2012. 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