{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:01:35Z","timestamp":1777928495249,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Up to 40% of the world populations are affected by allergic rhinitis (AR). Interplay between genetics, epigenetics, and environmental factors leads to allergic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      In this study, we evaluated the accompaniment between polymorphic variants of\n                      <jats:italic toggle=\"yes\">IL-13<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">IL-4<\/jats:italic>\n                      and aeroallergens among Iranian-Azeri children and adolescent in AR's risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Five-hundred AR patients and 300 healthy individuals were enrolled in this study after diagnosis via blood testing for IgE and skin prick test by subspecialty of Allergy and Immunology from Azerbaijan, northwest of Iran, from 2017 to 2019. Genomic DNA was prepared from all samples for genotyping of\n                      <jats:italic toggle=\"yes\">IL-4<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">IL-13<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified genetic variation of\n                      <jats:italic toggle=\"yes\">IL-13<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">IL-4<\/jats:italic>\n                      and important aeroallergens that could increase the AR risk during childhood and adolescent. The risk of AR increased in the subjects with +2044GA genotype of\n                      <jats:italic toggle=\"yes\">IL13<\/jats:italic>\n                      [adjusted odds ratio (OR), 1.80; 95% confidence interval (CI), 0.97\u20133.33] and \u2212590CT genotype of\n                      <jats:italic toggle=\"yes\">IL4<\/jats:italic>\n                      (adjusted OR, 1.94; 95% CI, 1.00\u20133.87) in childhoods, compared with the control subjects. However, none of genotypes and allele frequencies of\n                      <jats:italic toggle=\"yes\">IL4<\/jats:italic>\n                      \u2212590C\/T and\n                      <jats:italic toggle=\"yes\">IL13<\/jats:italic>\n                      +2044G\/A polymorphisms revealed significant variation between the AR patients and controls in adulthood. The frequency of sensitization to pollens was high in all genotypes of\n                      <jats:italic toggle=\"yes\">IL4<\/jats:italic>\n                      \u2212590C\/T and\n                      <jats:italic toggle=\"yes\">IL13<\/jats:italic>\n                      +2044G\/A polymorphisms in both age groups of AR patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      AR is considered to be the most common form of atopic disease. Susceptible individuals had family history of allergic disease and indicated sensitivity to various environmental factors. In this study, pollen and feather played an important role in occurrence of AR. Childhood with GA at\n                      <jats:italic toggle=\"yes\">IL13<\/jats:italic>\n                      +2044 and CT at\n                      <jats:italic toggle=\"yes\">IL4<\/jats:italic>\n                      \u2212590 are at increased risk for AR. Moreover, further studies with more samples are required to confirm our findings and also to help us develop new procedure for genetically detecting more efficient proceedings of prevention and intervention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2019.1099","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T14:54:22Z","timestamp":1584716062000},"page":"33-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationships Between IL-13 and IL-4 Genotypes and Aeroallergens with Risk of Allergic Rhinitis in Iranian-Azeri"],"prefix":"10.1177","volume":"33","author":[{"given":"Nazila","family":"Valatabar","sequence":"first","affiliation":[{"name":"Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadali","family":"Hosseinpourfeizi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Safaralizadeh","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Sadeghi-Shabestari","sequence":"additional","affiliation":[{"name":"Immunology Research Center of Tabriz, TB and Lung Research Center of Tabriz, Children Hospital, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-015-0828-5"},{"issue":"1","key":"e_1_3_5_3_2","first-page":"25","article-title":"Genetic aspects of allergic rhinitis","volume":"19","author":"Davila I","year":"2009","unstructured":"Davila I, , Mullol J, , Ferrer M, et al. 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