{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:01:50Z","timestamp":1777928510184,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Echinocandin antifungal medications including micafungin are being used more commonly in the treatment of invasive fungal infections in both pediatric and adult patients. Micafungin is also a first-line therapeutic option for candidemia and antifungal prophylaxis in a variety of clinical settings. Hypersensitivity reactions have not been well described; however, isolated cases have been reported. No cases of desensitization to echinocandins have been previously described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>In this report, we described a 14-year-old female with high-risk pre-B cell acute lymphoblastic leukemia diagnosed with pulmonary aspergillosis. She developed a hypersensitivity reaction to micafungin, which was deemed first-line therapy for the infection. A rapid intravenous desensitization protocol was successfully completed without reactions. The patient completed the remaining 2 months of therapy without reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This report outlines the first report of a successful desensitization to micafungin or any echinocandin. This is a safe method of completing antifungal therapy in a patient with echinocandin hypersensitivity and may be considered for other patients with micafungin hypersensitivities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2020.1204","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T12:21:46Z","timestamp":1595852506000},"page":"106-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful Rapid Desensitization to Micafungin in a Pediatric Patient"],"prefix":"10.1177","volume":"34","author":[{"given":"Stephanie L.","family":"Ward","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA."},{"name":"The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle C.","family":"Maciag","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts, USA."},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Boston Children's Hospital, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts, USA."},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Dioun","family":"Broyles","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Boston Children's Hospital, Boston, Massachusetts, USA."},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M237"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/501020"},{"key":"e_1_3_3_4_2","first-page":"62e1","article-title":"Clinical practice guidelines for the management of candidiasis: 2016 update by the Infectious Disease Society of America","author":"Pappas PG","unstructured":"Pappas PG, , Kauffman CA, , Andes DR, et al. Clinical practice guidelines for the management of candidiasis: 2016 update by the Infectious Disease Society of America. Clin Infect Dis 2016 Feb, 15; 62e1\u2013e50.","journal-title":"Clin Infect Dis 2016 Feb"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/422312"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/11209970-000000000-00000"},{"key":"e_1_3_3_7_2","unstructured":"Astellas Pharma US Inc. Mycamine (micafungin sodium) prescribing information. Northbrook IL 2019."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182127eaf"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03825.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-011-0239-y"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155208101122"}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2020.1204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2020.1204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2020.1204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:14:52Z","timestamp":1777677292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2020.1204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1089\/ped.2020.1204"],"URL":"https:\/\/doi.org\/10.1089\/ped.2020.1204","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}