{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:06:22Z","timestamp":1790143582574,"version":"4.0.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Increased lactate concentrations are directly related to the severity of shock and mortality rates. There are limited data regarding the prognostic value of lactate among lower respiratory tract infections. We aimed to investigate the impact of lactate levels on admission on the clinical outcomes of children with lower respiratory tract infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective study of hospitalized patients aged 1\u201312 months. We recorded data on patient demographics, clinical, laboratory, treatment, and outcomes. The primary outcome measure was the length of hospital stay, and the secondary outcome was transfer to the pediatric intensive care unit (PICU) and\/or mortality rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 304 infants were included in the study. There were 198 infants with lactate levels of &gt;2\u2009mmol\/L. Lactic acidosis was present in 6 infants, with a mean hospital stay of 8\u2009\u00b1\u20093 days. Only 1 (0.3%) patient required intubation, and 5 (1.6%) were transferred to the PICU. The overall mortality rate was 0%. Lactate levels (\u22642 and &gt;2\u2009mmol\/L) were not related to the length of hospital stay, transfer to PICU\/discharge, and the need for intubation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.16, 0.8, and 0.46, respectively). The length of hospital stay was not correlated with lactate levels on admission (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.84), pCO\n                      <jats:sub>2<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.03,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.52), pH (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.07,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.19), C-reactive protein (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.06,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.28), and oxygen saturation (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u22120.02,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.72).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Lactate levels on admission did not predict the length of hospital stay in children with lower respiratory infections and were not related to the need for transfer to the intensive care unit. We suggest using lactate levels in combination with clinical, laboratory, and physical examination findings as predictors of disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2021.0008","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T14:41:19Z","timestamp":1624027279000},"page":"68-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship Between Lactate Levels and Length of Hospital Stay in Infants with Lower Respiratory Tract Infection"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-6375","authenticated-orcid":false,"given":"Emek","family":"Uyur Yal\u00e7in","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-6420","authenticated-orcid":false,"given":"Furkan","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-1748","authenticated-orcid":false,"given":"Esra","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-8208","authenticated-orcid":false,"given":"Selda","family":"Se\u00e7im","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-3583","authenticated-orcid":false,"given":"Rabia G\u00f6n\u00fcl","family":"Sezer Yamanel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1403-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182211aed"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304338"},{"key":"e_1_3_4_5_2","first-page":"1151","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016 [published correction appears in Lancet. 2017; 28;390:e38]","volume":"390","author":"GBD 2016 Causes of Death Collaborators","year":"2017","unstructured":"GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016 [published correction appears in Lancet. 2017; 28;390:e38]. Lancet, 2017; 390:1151\u20131210.","journal-title":"Lancet"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300920"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-010-9724-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.04.029"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222591"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.08.013"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/JETS.JETS_103_16"},{"key":"e_1_3_4_12_2","unstructured":"Kocaba\u015f E Do\u011fru-Ers\u00f6z D Karako\u00e7 F et al. Turkish Thoracic Society T\u00fcrk Toraks Dernegi \u00c7ocukluklarda Toplumda Geli\u015fen Pn\u00f6moni Tan\u0131 ve Tedavi Uzla\u015f\u0131 Raporu. Turk Thorac J 2009; 10 S1\u2013S24."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3182196aa2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0344"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05878-6"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2018-0260"}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2021.0008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:14Z","timestamp":1777677314000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2021.0008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1089\/ped.2021.0008"],"URL":"https:\/\/doi.org\/10.1089\/ped.2021.0008","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}