{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:06Z","timestamp":1777928526706,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We describe a rare case involving paracetamol, a commonly used drug worldwide. Increased paracetamol consumption increases the risk of adverse drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>This is a case of a 9-year-old girl who visited the emergency department due to sudden onset sneezing, nasal itching, urticaria, and angioedema after paracetamol ingestion. The diagnostic and etiologic studies revealed an immunoglobulin E (IgE)-mediated hypersensitivity mechanism to paracetamol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Few cases of this phenomenon have been reported in previous literature. As confirmed in this study, a negative skin prick test did not exclude hypersensitivity, and conducting intradermal tests (IDTs) increased diagnostic accuracy. The patient had a positive IDT, confirming the underlying IgE-mediated reaction. The follow-up of a confirmed paracetamol hypersensitivity implies patient education about avoidance of any paracetamol-containing formulation, including combination products and clarification of available alternative drugs. This is likely the first publication documenting IgE-mediated paracetamol allergy in pediatric patients. We intend to underline the clinical benefits of diagnostic confirmation toward suspected drug hypersensitivity reactions in children, a particularly useful topic for pediatricians and pediatric allergists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2021.0027","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T14:41:19Z","timestamp":1624027279000},"page":"80-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Paracetamol Allergy: A Case of a 9-Year-Old Female with a History of Atopy"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-4404","authenticated-orcid":false,"given":"Ariana","family":"Teles","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Ribeiro-Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Branco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Rita","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Allergy and Immunology, Hospital Santa Luzia de Viana do Castelo, Viana do Castelo, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"395","article-title":"Hypersensitivity to antipyretics: pathogenesis, diagnosis, and management","volume":"23","author":"Lee QU","year":"2017","unstructured":"Lee QU. Hypersensitivity to antipyretics: pathogenesis, diagnosis, and management. Hong Kong Med J, 2017; 23:395.","journal-title":"Hong Kong Med J"},{"key":"e_1_3_3_3_2","first-page":"163","article-title":"Selective anaphylaxis to paracetamol in a child","volume":"44","author":"Couto M","year":"2012","unstructured":"Couto M, , Gaspar A, , Morais-Almeida M. Selective anaphylaxis to paracetamol in a child. Eur Ann Allergy Clin Immunol, 2012; 44:163.","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13330"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy7010012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-018-0202-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-08-18-4689"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000335213"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62580-X"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000487556"},{"key":"e_1_3_3_13_2","first-page":"163","article-title":"Hipersensibilidade a anti-inflamat\u00f3rios n\u00e3o esteroides revisitada-Aspectos cl\u00ednicos laboratoriais \u00e0 luz da nova classifica\u00e7\u00e3o da EAACI","volume":"24","author":"Cardoso BK","year":"2016","unstructured":"Cardoso BK, , Tomaz E, , Correia S, et al. Hipersensibilidade a anti-inflamat\u00f3rios n\u00e3o esteroides revisitada-Aspectos cl\u00ednicos laboratoriais \u00e0 luz da nova classifica\u00e7\u00e3o da EAACI. 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