{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:34:22Z","timestamp":1780317262218,"version":"3.54.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n Background:<\/jats:title>\n Although serum levels of squamous cell carcinoma antigen (SCCA) are elevated in atopic dermatitis (AD), their clinical utility has not been fully elucidated.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Thirty-three cases of AD who admitted to our hospital were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Baseline characteristics on admission were as follows: median age 19 months [interquartile range (IQR), 12\u201352 months], median objective severity scoring of atopic dermatitis (O-SCORAD) 19.2 (IQR, 4.2\u201336.0), and median serum SCCA levels 3.2\u2009ng\/mL (IQR, 2.1\u20136.8\u2009ng\/mL). O-SCORAD significantly correlated with serum SCCA levels (rs\u2009=\u20090.865,\n P<\/jats:italic>\n \u2009<\u20090.001). In 9 cases whose information before and after treatment was available (median interval, 3 days; IQR 2\u20135 days), median serum SCCA levels significantly decreased from 8.0 to 2.0\u2009ng\/mL (\n P<\/jats:italic>\n \u2009=\u20090.008) after the treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Serum levels of total SCCA rapidly declined in response to the treatment and could be used as a real-time biomarker in childhood AD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/ped.2021.0049","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T14:57:27Z","timestamp":1629471447000},"page":"102-105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A Serum Level of Squamous Cell Carcinoma Antigen as a Real-Time Biomarker of Atopic Dermatitis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-2381","authenticated-orcid":false,"given":"Masaki","family":"Shimomura","sequence":"first","affiliation":[{"name":"Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Okura","sequence":"additional","affiliation":[{"name":"Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00851.x"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041102"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.021"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.06.016"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01253.x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.12.003"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/172460089901400207"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04363.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.11.002"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02353.x"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077726"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011065"}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2021.0049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:17Z","timestamp":1777677317000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2021.0049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1089\/ped.2021.0049"],"URL":"https:\/\/doi.org\/10.1089\/ped.2021.0049","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}