{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:17Z","timestamp":1777928537094,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The reversibility of bronchial obstruction is needed to diagnose asthma. Bronchodilation (BD) testing is, therefore, used in asthma work-up. This study explored the benefit of performing BD testing in asthmatic children without bronchial obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included 60 subjects with asthma and normal lung function, 13 (21.7%) females and 47 (78.3%) males; the mean age was 11.5 years, 26 were adolescents, and 34 were children. Lung function, symptoms, use of asthma medications, type 2 inflammation, and asthma control were assessed in all subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eleven (18%) subjects positively responded to BD testing. Fifty-five percent of subjects were uncontrolled based on Global Initiative for Asthma (GINA) criteria. The multivariate analysis identified 2 factors associated with a positive response to BD testing: FEV\n                      <jats:sub>1<\/jats:sub>\n                      [odds ratio (OR)\u2009=\u20090.91) and ACT (OR\u2009=\u20090.79).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study showed that BD testing could give additional helpful information in clinical practice. In addition, uncontrolled asthma, based on GINA criteria, was prevalent in children with normal lung function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2021.0222","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T16:54:28Z","timestamp":1648054468000},"page":"8-11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Bronchodilation Testing Routinely Useful in All Asthmatic Children?"],"prefix":"10.1177","volume":"35","author":[{"given":"Maria Angela","family":"Tosca","sequence":"first","affiliation":[{"name":"Pediatric Allergy Center, Istituto Giannina Gaslini, Genoa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Schiavetti","sequence":"additional","affiliation":[{"name":"Health Science Department, University of Genoa, Genoa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Binelli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Center, Istituto Giannina Gaslini, Genoa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[{"name":"Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Universit\u00e0 della Campania Luigi Vanvitelli, Napoli, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Ciprandi","sequence":"additional","affiliation":[{"name":"Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2021.0031"},{"key":"e_1_3_4_3_2","unstructured":"Global Initiative for Asthma. GINA guidelines. Global Strategy for Asthma Management and Prevention. 2021. Available at: www.ginasthma.org Accessed January22 2022."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04173-2020"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2019.11.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1108436"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.05.004"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029934"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.08.014"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.050"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01326-2019"},{"key":"e_1_3_4_12_2","first-page":"1","article-title":"A compendium and review of pediatric pulmonary function testing assessment opportunities for asthma","author":"Hopp RJ","year":"2021","unstructured":"Hopp RJ, , Wilson M, , Pasha MA. A compendium and review of pediatric pulmonary function testing assessment opportunities for asthma. J Asthma, 2021; 1\u20136.","journal-title":"J Asthma"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2021.1906653"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25162"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","unstructured":"Tosca MA Schiavetti I Ciprandi G. The role of bronchodilation testing in children and adolescents with asthma in clinical practice. J Asthma 2022 (in press).","DOI":"10.1080\/02770903.2021.1980582"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v49i1.14"}],"updated-by":[{"DOI":"10.1089\/ped.2021.0222.correx","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000}}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2021.0222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2021.0222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:30Z","timestamp":1777677330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2021.0222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1089\/ped.2021.0222"],"URL":"https:\/\/doi.org\/10.1089\/ped.2021.0222","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}