{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:58Z","timestamp":1785575758960,"version":"3.56.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>\n                      An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum carrot-specific immunoglobulin E level was 0.19 UA\/mL. The prick-by-prick test for raw carrots was positive\n                      <jats:bold>(<\/jats:bold>\n                      wheal diameter: 4\u2009mm\n                      <jats:bold>)<\/jats:bold>\n                      . The patient developed urticaria after exercise provocation tests following ingestion of raw carrots. Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21\u201366\u2009kDa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2022.0122","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T12:00:14Z","timestamp":1669723214000},"page":"166-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots: A Case Report"],"prefix":"10.1177","volume":"35","author":[{"given":"Nami","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan."},{"name":"Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-6696","authenticated-orcid":false,"given":"Jun","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kumamoto University Hospital, Kumamoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Aichi, Japan."},{"name":"General Research and Development Institute, Hoyu Co., Ltd., Aichi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Aichi, Japan."},{"name":"General Research and Development Institute, Hoyu Co., Ltd., Aichi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Beppu University, Oita, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Aichi, Japan."},{"name":"General Research and Development Institute, Hoyu Co., Ltd., Aichi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Aichi, Japan."},{"name":"General Research and Development Institute, Hoyu Co., Ltd., Aichi, 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