{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:29Z","timestamp":1777928549854,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The clinical course of COVID-19 in patients with congenital central hypoventilation syndrome (CCHS) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a cross-sectional questionnaire study in 43 patients with CCHS who had COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median age of patients was 11 [interquartile range (IQR) 6\u201322] years and 53.5% required assisted ventilation (AV) through tracheostomy. Disease severity ranged from asymptomatic infection (12%) to severe illness with hypoxemia (33%) and hypercapnia requiring emergency care\/hospitalization (21%), increased AV duration (42%), increased ventilator settings (12%), and supplemental oxygen demand (28%). The median duration to return to baseline AV (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920) was 7 (IQR 3\u201310) days. Patients with polyalanine repeat mutations required increased AV duration compared with those with nonpolyalanine repeat mutations (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.048). Patients with tracheostomy required increased oxygen during illness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.02). Patients aged \u226518 years took longer to return to baseline AV (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study suggests that all patients with CCHS should be vigilantly monitored during COVID-19 illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2023.0004","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T09:59:37Z","timestamp":1684490377000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features of COVID-19 in Patients with Congenital Central Hypoventilation Syndrome"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-2807","authenticated-orcid":false,"given":"Ajay S.","family":"Kasi","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Riccitelli","sequence":"additional","affiliation":[{"name":"Congenital Central Hypoventilation Syndrome (CCHS) Network, Encinitas, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila S.","family":"Kun","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrianna L.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Keens","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokesh","family":"Guglani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01460-2"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1069ST"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-305OC"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.11.003"},{"key":"e_1_3_6_6_2","unstructured":"Centers for Disease Control and Prevention. COVID Data Tracker. Available from: https:\/\/covid.cdc.gov\/covid-data-tracker\/#datatracker-home [Last accessed: January3 2023]."},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053418"},{"key":"e_1_3_6_8_2","unstructured":"Centers for Disease Control and Prevention. People with Certain Medical Conditions. 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Case report: An infant with congenital central hypoventilation syndrome and COVID-19. Resid Pediatr, 2020; 10(3):1\u20133; doi: DOI: 10.25060\/residpediatr-2020.v10n3-376","journal-title":"Resid Pediatr"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01742-6"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15270"},{"key":"e_1_3_6_19_2","unstructured":"Centers for Disease Control and Prevention. Long COVID or Post-COVID Conditions. 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