{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:52:23Z","timestamp":1779933143844,"version":"3.53.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Cases of cow's milk allergy (CMA) who reacted to measles or measles, mumps, and rubella (MMR) vaccines containing alpha-lactalbumin have been reported. The purpose of this study was to assess patients with CMA who received measles or MMR vaccines containing alpha-lactalbumin, as well as the characteristics of those who developed reactions to these vaccines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Patients followed up in the allergy clinic for CMA and who received measles or MMR vaccines containing alpha-lactalbumin at 9 or 12 months of age were included in the study, and their characteristics were analyzed retrospectively from the hospital registry system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty-nine patients were included in the study. Six patients received the measles vaccine, whereas 43 patients received the MMR vaccine containing alpha-lactalbumin. Vaccine skin tests were performed on these 6 patients. One patient had a positive intradermal test, so an alternative vaccine not containing alpha-lactalbumin was administered. The other 5 patients were vaccinated, and no reaction was observed. Anaphylaxis was observed in 3 of 43 patients who received the MMR vaccine containing alpha-lactalbumin. In all of these patients, the first reaction to dairy products was anaphylaxis. In 2 of those patients, cow's milk-specific IgE (spIgE) levels were &gt;100 kU\/L, and alpha-lactalbumin-spIgE levels were also high at 97 and 90 kU\/L. The third patient's cow's milk-spIgE level was 15.9 kU\/L, whereas the alpha-lactalbumin-spIgE level was 0.04 kU\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Especially in patients with an initial reaction of anaphylaxis to dairy products and high cow's milk-spIgE levels, the risk of reaction is high with the MMR vaccine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2023.0035","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T17:04:51Z","timestamp":1689095091000},"page":"90-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Children with Cow's Milk Allergy Who Received Measles or Measles, Mumps, and Rubella Vaccines Containing Alpha-Lactalbumin"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-0793","authenticated-orcid":false,"given":"Ezgi","family":"Ulusoy Severcan","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, Dr. Sami Ulus Maternity and Children Training and Research Hospital, University of Health Sciences, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Ertugrul","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, Dr. Sami Ulus Maternity and Children Training and Research Hospital, University of Health Sciences, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, Department of Pediatrics, Dr. Sami Ulus Maternity and Children Training and Research Hospital, University of Health Sciences, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051051"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-020-1916-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v49i3.74"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0120-5"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13631"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.86"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.01.004"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2021.06.001"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-019-02981-w"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13821"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2019.0993"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14840"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.971"}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2023.0035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2023.0035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2023.0035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:53Z","timestamp":1777677353000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2023.0035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1089\/ped.2023.0035"],"URL":"https:\/\/doi.org\/10.1089\/ped.2023.0035","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}