{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:49Z","timestamp":1777928569263,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The atopic march refers to the progression of allergic disorders from atopic dermatitis (AD) in early childhood to food allergies, eosinophilic esophagitis (EOE), and later respiratory allergies such as asthma and allergic rhinitis. Mutations in the filaggrin gene, which compromise skin barrier function, are strongly associated with this progression and contribute to allergic sensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>We introduce a 7-year-old boy with severe AD, food anaphylaxis, EOE, allergic rhinitis, and asthma associated with a filaggrin mutation (c.5152C&gt;T). His clinical course illustrates the atopic march, with initial skin involvement progressing to gastrointestinal and respiratory allergic manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Understanding the genetic factors that drive this progression may help identify targets for early intervention to prevent the further development of allergic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ped.2024.0118","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:07:35Z","timestamp":1744110455000},"page":"61-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Atopic March in a Case of Filaggrin Gene Mutation"],"prefix":"10.1177","volume":"38","author":[{"given":"Anahita","family":"Razaghian","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Pediatrics, Hakim Children Hospital, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Moradi","sequence":"additional","affiliation":[{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Children\u2019s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Allahverdi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Center of Excellence, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Khansari Asadabadi","sequence":"additional","affiliation":[{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Children\u2019s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Children\u2019s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheleh","family":"Shokouhi Shoormasti","sequence":"additional","affiliation":[{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Children\u2019s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Fazlollahi","sequence":"additional","affiliation":[{"name":"Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran."},{"name":"Children\u2019s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.037"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.006"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.01.001"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/allergies1020009"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.011"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.067"},{"key":"e_1_3_7_8_2","unstructured":"Rothenberg M. 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