{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:57Z","timestamp":1777928577674,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>The United States Food and Drug Administration (FDA) proposed removing oral phenylephrine (PE) from over-the-counter single-agent and combination products because it is ineffective at FDA-approved doses to treat sinonasal congestion. Health care providers make thousands of recommendations per month for phenylephrine-containing over-the-counter products to treat adults and children with signs and symptoms of the common cold, specifically nasal congestion. Health care providers may feel compelled by parents to recommend over-the-counter medications to treat the common cold in children, despite resources suggesting those products may be mildly effective, ineffective, or possibly unsafe. The objective of this Pharmacotherapy Update is to suggest alternative treatments to PE in children with the common cold and nasal congestion.<\/jats:p>","DOI":"10.1089\/ped.2025.0031","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T12:09:21Z","timestamp":1749816561000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["What Are Alternatives to Oral Phenylephrine in Children?"],"prefix":"10.1177","volume":"38","author":[{"given":"Julia","family":"Young","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences, The University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nationwide Children\u2019s Hospital, Columbus, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-8238","authenticated-orcid":false,"given":"Paul M.","family":"Boylan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences, The University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Pharmacy Times. OTC Guide. 2024. Available from: https:\/\/www.pharmacytimes.com\/otcguide [Last accessed: March17 2025]."},{"key":"e_1_3_4_3_2","volume-title":"Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care","author":"Scolaro KL","year":"2025","unstructured":"Scolaro KL. . Colds and allergy. In: Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care. (Krinsky DL, , Ferreri SP, , Hemstreet BA, et al. eds.) American Pharmacists Association: Washington D.C.; 2025."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.07.007"},{"issue":"2","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2008.06.003","article-title":"The diagnosis and management of rhinitis: An updated practice parameter","volume":"122","author":"Wallace DV","year":"2008","unstructured":"Wallace DV, , Dykewicz MS, , Bernstein DI, et al.; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: An updated practice parameter. J Allergy Clin Immunol, 2008; 122(2 Suppl):S1\u2013S84; doi: 10.1016\/j.jaci.2008.06.003","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41533-017-0018-x","article-title":"Management of respiratory tract infections in young children\u2014A qualitative study of primary care providers\u2019 perspectives","volume":"27","author":"Biezen R","year":"2017","unstructured":"Biezen R, , Brijnath B, , Grando D, et al. Management of respiratory tract infections in young children\u2014A qualitative study of primary care providers\u2019 perspectives. NPJ Prim Care Respir Med, 2017; 27(1):15; doi: 10.1038\/s41533-017-0018-x","journal-title":"NPJ Prim Care Respir Med"},{"key":"e_1_3_4_7_2","volume-title":"Adrenergic Agonists and Antagonists","author":"Tilley DG","year":"2023","unstructured":"Tilley DG, , Houser SR, , Koch WJ. Adrenergic Agonists and Antagonists. McGraw Hill Medical: Philadelphia, PA; 2023."},{"key":"e_1_3_4_8_2","volume-title":"Katzung\u2019s Pharmacology Examination & Board Review","author":"Kruidering-Hall M","year":"2024","unstructured":"Sympathomimetics. In: Katzung\u2019s Pharmacology Examination & Board Review. (Kruidering-Hall M, , Katzung BG, , Lalchandani Tuan R, et al. eds.) McGraw Hill Medical: Philadelphia, PA; 2024."},{"key":"e_1_3_4_9_2","unstructured":"US Food and Drug Administration. Over-the-Counter Monograph M012: Cold Cough Allergy Bronchodilator and Antiasthmatic Drug Products for Over-the-Counter Human Use. Washington D.C.; 2022. Available from: https:\/\/dps-admin.fda.gov\/omuf\/omuf\/sites\/omuf\/files\/primary-documents\/2022-10\/OTC%20Monograph_M012-Cough%20Cold%20Allergy%20Bronchodilator%20and%20Antiasthmatic%20Drug%20Products%20for%20OTC%20Human%20Use%2010.14.2022_0.pdf [Last accessed: March17 2025]."},{"issue":"3","key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jac5.2080","article-title":"What we have learned from trying to remove oral phenylephrine from the market","volume":"8","author":"Hatton RC","year":"2025","unstructured":"Hatton RC, , Hendeles L. What we have learned from trying to remove oral phenylephrine from the market. J Am Coll Clin Pharm, 2025; 8(3):214\u2013223; doi: 10.1002\/jac5.2080","journal-title":"J Am Coll Clin Pharm"},{"key":"e_1_3_4_11_2","unstructured":"US Food and Drug Administration. Legal requirements for the sale and purchase of drug products containing pseudoephedrine ephedrine and phenylpropanolamine. Washington D.C.; 2005. Available from: https:\/\/www.fda.gov\/drugs\/information-drug-class\/legal-requirements-sale-and-purchase-drug-products-containing-pseudoephedrine-ephedrine-and [Last accessed: March17 2025]."},{"issue":"10","key":"e_1_3_4_12_2","first-page":"CD009612","article-title":"Nasal decongestants in monotherapy for the common cold","volume":"10","author":"Deckx L","year":"2016","unstructured":"Deckx L, , De Sutter AI, , Guo L, et al. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev, 2016; 10(10):CD009612; doi: 10.1002\/14651858.CD009612.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.06.014"},{"issue":"3","key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1345\/aph.1H679","article-title":"Efficacy and safety of oral phenylephrine: Systematic review and meta-analysis","volume":"41","author":"Hatton RC","year":"2007","unstructured":"Hatton RC, , Winterstein AG, , McKelvey RP, et al. Efficacy and safety of oral phenylephrine: Systematic review and meta-analysis. Ann Pharmacother, 2007; 41(3):381\u2013390; doi: 10.1345\/aph.1H679","journal-title":"Ann Pharmacother"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.05.007"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.02.014"},{"key":"e_1_3_4_17_2","unstructured":"US Food and Drug Administration. FDA proposes ending use of oral phenylephrine as OTC monograph nasal decongestant active ingredient after extensive review. Washington D.C.; 2024. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-proposes-ending-use-oral-phenylephrine-otc-monograph-nasal-decongestant-active-ingredient-after [Last accessed: March17 2025]."},{"issue":"9","key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/jama.2023.27932","article-title":"Trends in phenylephrine and pseudoephedrine sales in the US","volume":"331","author":"Anderson TS","year":"2024","unstructured":"Anderson TS, , Suda KJ, , Gellad WF, et al. Trends in phenylephrine and pseudoephedrine sales in the US. JAMA, 2024; 331(9):796\u2013798; doi: 10.1001\/jama.2023.27932","journal-title":"JAMA"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"k3786","DOI":"10.1136\/bmj.k3786","article-title":"What treatments are effective for common cold in adults and children","volume":"363","author":"van Driel ML","year":"2018","unstructured":"van Driel ML, , Scheire S, , Deckx L, et al. What treatments are effective for common cold in adults and children? Bmj, 2018; 363:k3786; doi: 10.1136\/bmj.k3786","journal-title":"Bmj"},{"key":"e_1_3_4_20_2","unstructured":"Centers for Disease Control and Prevention. About Common Cold. Atlanta GA; 2024. Available from: https:\/\/www.cdc.gov\/common-cold\/about\/index.html [Last accessed: March17 2025]."},{"issue":"11","key":"e_1_3_4_21_2","first-page":"CD009345","article-title":"Antihistamines for the common cold","volume":"2015","author":"De Sutter AI","year":"2015","unstructured":"De Sutter AI, , Saraswat A, , van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev, 2015; 2015(11):CD009345; doi: 10.1002\/14651858.CD009345.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/000348947708600306","article-title":"A system of rhinomanometry in the clinical evaluation of nasal decongestants","volume":"86","author":"Dressler WE","year":"1977","unstructured":"Dressler WE, , Myers T, , Rankell AS, et al. A system of rhinomanometry in the clinical evaluation of nasal decongestants. Ann Otol Rhinol Laryngol, 1977; 86(3 Pt 1):310\u2013317; doi: 10.1177\/000348947708600306","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_3_4_23_2","unstructured":"Pediatric and Neonatal Lexi-Drugs. Wolters Kluwer Health: 2025. Available from: http:\/\/www.online.lexi.com"},{"key":"e_1_3_4_24_2","unstructured":"US Food and Drug Administration. Is Rinsing Your Sinuses with Neti Pots Safe? Bethesda MD; 2023. Available from: https:\/\/www.fda.gov\/consumers\/consumer-updates\/rinsing-your-sinuses-neti-pots-safe [Last accessed: April20 2025]."},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1472"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199803000-00019"},{"issue":"12","key":"e_1_3_4_27_2","first-page":"e75464","article-title":"Nasal irrigation with saline solution for pediatric acute upper respiratory infections: A systematic review","volume":"16","author":"Cruz M","year":"2024","unstructured":"Cruz M, , Roteia C, , Marques Ferreira A, et al. Nasal irrigation with saline solution for pediatric acute upper respiratory infections: A systematic review. Cureus, 2024; 16(12):e75464; doi: 10.7759\/cureus.75464","journal-title":"Cureus"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13223-018-0258-5","article-title":"Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: A randomized, placebo-controlled trial","volume":"14","author":"Schenkel EJ","year":"2018","unstructured":"Schenkel EJ, , Ciesla R, , Shanga GM. Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: A randomized, placebo-controlled trial. Allergy Asthma Clin Immunol, 2018; 14:34; doi: 10.1186\/s13223-018-0258-5","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/15563650600671696"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1601"}],"container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ped.2025.0031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2025.0031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ped.2025.0031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:16:27Z","timestamp":1777677387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ped.2025.0031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1089\/ped.2025.0031"],"URL":"https:\/\/doi.org\/10.1089\/ped.2025.0031","relation":{},"ISSN":["2151-321X","2151-3228"],"issn-type":[{"value":"2151-321X","type":"print"},{"value":"2151-3228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}