{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:58:25Z","timestamp":1785178705931,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["PHAGE: Therapy, Applications, and Research"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>\n                    Brucellosis caused by\n                    <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                    organisms is a major zoonosis globally. It causes heavy losses through abortions, delayed conception, and infertility in animals.\n                    <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                    is an intracellular bacterium. Antibiotic therapy for bovine Brucellosis is expensive and may sometimes be ineffective as\n                    <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                    can become resistant. Once infected, the animal may remain carrier and shed bacteria in milk, semen, and uterine discharges spreading infection to others for a long period. The live attenuated\n                    <jats:italic toggle=\"yes\">Brucella abortus<\/jats:italic>\n                    strain S19 organisms that are commonly used as a vaccine were employed to deliver a broad acting lytic brucellaphage inside the phagocytes\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    to reach the virulent\n                    <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                    hiding intracellularly. The phage pulsed vaccine induced sustained and significantly high titers of anti-\n                    <jats:italic toggle=\"yes\">Brucella<\/jats:italic>\n                    antibodies compared with the untreated animals and animals vaccinated with S19 vaccine alone as estimated by standard tube agglutination test, microagglutination test, indirect hemagglutination assay test, and enzyme-linked immunosorbent assay. The current investigation is perhaps the first systematic attempt whereby efficacy of brucellaphage pulsed vaccine preparation in induction of specific antibody response was evaluated in cattle.\n                  <\/jats:p>","DOI":"10.1089\/phage.2020.0018","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T12:23:06Z","timestamp":1608639786000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Phage Targeting Therapy of Brucellosis on Host Antibody Response in Cattle"],"prefix":"10.1177","volume":"1","author":[{"given":"Anju","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Mohan","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Ludhiana, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Kollannur J D Rathore R Chauhan RS. Epidemiology and economics of brucellosis in animals and its zoonotic significance. In: Proceedings of XIII International Congress in Animal Hygiene. Tartu Estonia: International Society for Animal Hygiene; 2007:466\u2013468."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.5455\/vetworld.2013.51-52"},{"issue":"1","key":"e_1_3_4_4_2","first-page":"22","article-title":"Seroprevalence of brucellosis in different animal species of Kailali district Nepal","volume":"2","author":"Pandeya YR","year":"2013","unstructured":"Pandeya YR, , Joshi DD, , Dhakal S, et al. Seroprevalence of brucellosis in different animal species of Kailali district Nepal. 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