{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:05:21Z","timestamp":1777928721303,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["PHAGE: Therapy, Applications, and Research"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      There are no verified lytic\n                      <jats:italic toggle=\"yes\">Staphylococcus pseudintermedius<\/jats:italic>\n                      phages in the literature and few temperate phage genomes in databases.\n                      <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                      is an opportunistic zoonotic pathogen of great importance in veterinary and human medicine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      We discovered phages against canine-derived\n                      <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                      isolates by screening dog feces, hair, and skin swabs. Fourteen new phages were isolated and characterized by genomic analysis, transmission electron microscopy, and host range determination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three phages\u2014DH2, DH5, and DS10, a phage K variant\u2014were predicted lytic by sequencing, a designation supported by mitomycin C induction. All three are\n                      <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      polyvalent phages, with DH2 and DS10 being strong killers of both species.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      We report discovery of the first verified lytic\n                      <jats:italic toggle=\"yes\">S. pseudintermedius<\/jats:italic>\n                      phages and suggest dog hair as a novel reservoir. DH2, DH5, and DS10 are promising candidates toward developing an anti-\n                      <jats:italic toggle=\"yes\">Staphylococcal<\/jats:italic>\n                      phage cocktail.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/phage.2022.0004","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T10:25:28Z","timestamp":1655720728000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Discovery of the First Lytic\n                    <i>Staphylococcus pseudintermedius<\/i>\n                    \/\n                    <i>Staphylococcus aureus<\/i>\n                    Polyvalent Bacteriophages"],"prefix":"10.1177","volume":"3","author":[{"given":"Haroldo","family":"Hernandez Santos","sequence":"first","affiliation":[{"name":"Tailored Antibacterials and Innovative Laboratories for Phage (\u03a6) Research (TAIL\u03a6R), Baylor College of Medicine, Houston, Texas, USA."},{"name":"Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Clark","sequence":"additional","affiliation":[{"name":"Tailored Antibacterials and Innovative Laboratories for Phage (\u03a6) Research (TAIL\u03a6R), Baylor College of Medicine, Houston, Texas, USA."},{"name":"Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austen","family":"Terwilliger","sequence":"additional","affiliation":[{"name":"Tailored Antibacterials and Innovative Laboratories for Phage (\u03a6) Research (TAIL\u03a6R), Baylor College of Medicine, Houston, Texas, USA."},{"name":"Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Maresso","sequence":"additional","affiliation":[{"name":"Tailored Antibacterials and Innovative Laboratories for Phage (\u03a6) Research (TAIL\u03a6R), Baylor College of Medicine, Houston, Texas, USA."},{"name":"Molecular Virology and Microbiology Department, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63413-0"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00828.x"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.01.039"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr367"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci8010011"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.008"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0399-9"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060592"},{"key":"e_1_3_6_10_2","article-title":"Assessment of animal diseases caused by bacteria resistant to antimicrobials: Dogs and cats","volume":"19","author":"Nielsen SS","year":"2021","unstructured":"EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, , Bicout DJ, et al. 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