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A promising alternative strategy is phage therapy in which limited applications has afforded lifesaving resolution from drug resistant pathogens. However, adoption of this strategy is hampered by narrow bacteriophage host ranges, and as with antibiotics, bacteria can acquire resistance to phage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      To address these issues, we isolated 25 broad-host range phages against multiple cystic fibrosis (CF)-derived\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      clinical strains thus promoting their application against conspecific pathogens. To investigate evolved resistance to phage in relation to antibiotic resistance, one CF-derived\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      strain was exposed to a lytic phage over a short time scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Trade-offs were observed in which evolved phage resistant\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      strains showed decreased resistance to antibiotics. These traits that likely reflect single nucleotide polymorphisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Results suggest phage and antibiotics may be a combined approach to treat bacterial infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/phage.2023.0022","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T13:59:30Z","timestamp":1708696770000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tradeoffs Between Evolved Phage Resistance and Antibiotic Susceptibility in a Highly Drug-Resistant Cystic Fibrosis-Derived\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Strain"],"prefix":"10.1177","volume":"5","author":[{"given":"Kaylee","family":"Wilburn","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cole B.","family":"Matrishin","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, University at Buffalo, Buffalo, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-3820","authenticated-orcid":false,"given":"Hans","family":"Wildschutte","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"CDC. 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