{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:52:04Z","timestamp":1784717524328,"version":"3.55.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2005,8]]},"abstract":"\n Objective:<\/jats:italic>\n Our aim was to investigate the effect of low-level laser therapy (LLLT), 650-nm wavelength, on acute inflammatory pleurisy.\n Background data:<\/jats:italic>\n There is only scattered evidence of anti-inflammatory effects from LLLT and dosage characteristics, and the effect on pleurisy inflammation has yet to be investigated.\n Methods:<\/jats:italic>\n A classical experimental model of pleurisy was used in a sample of 40 Balb male mice, randomly divided into five groups. Inflammation was induced by carrageenan (0.5 mg\/cavity) administered by intrathoracic injections. Four groups received the inflammatory agent, and one received injections of sterile saline solution. At 1, 2, and 3 h after injections, LLLT irradiation was performed, with the same power (2.5 mW), but different irradiation times. The energy densities at each of the three treatment sessions were 0 J\/cm\n 2<\/jats:sup>\n (placebo), 3 J\/cm\n 2<\/jats:sup>\n , 7.5 J\/cm\n 2<\/jats:sup>\n , and 15 J\/cm\n 2<\/jats:sup>\n , respectively.\n Results:<\/jats:italic>\n Total and differential cell analysis at 4 h after induction of pleurisy showed a significant reduction of inflammatory cell migration for all groups treated with active laser. However, at 4 h after injection, the most significant (\n p<\/jats:italic>\n < 0.001) reduction of leukocyte cell migration was seen in the 7.5 J\/cm\n 2<\/jats:sup>\n group, at 2.7 (95% CI: 2.5\u20132.9) \u00d7 10\n 6<\/jats:sup>\n , versus 7.9 (95% CI: 6.7\u20139.1) \u00d7 10\n 6<\/jats:sup>\n in the placebo control group. The greatest reduction of inflammatory cells was registered for neutrophils.\n Conclusions:<\/jats:italic>\n LLLT administered at 1\u20133 h after the induction of inflammatory pleurisy significantly reduces the inflammatory cell migration measured. Under these conditions and at 2.5 mW, 7.5 J\/cm\n 2<\/jats:sup>\n was more effective than 3 J\/cm\n 2<\/jats:sup>\n and 15 J\/cm\n 2<\/jats:sup>\n .\n <\/jats:p>","DOI":"10.1089\/pho.2005.23.377","type":"journal-article","created":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T12:16:18Z","timestamp":1126008978000},"page":"377-381","source":"Crossref","is-referenced-by-count":61,"title":["Spontaneous Effects of Low-Level Laser Therapy (650 nm) in Acute Inflammatory Mouse Pleurisy Induced by Carrageenan"],"prefix":"10.1177","volume":"23","author":[{"given":"Rodrigo Alvaro Brand\u00e3o","family":"Lopes-Martins","sequence":"first","affiliation":[{"name":"Research Group of Laser and Inflammation, Instituto de Pesquisa & Desenvolvimento, Universidade do Valedo Para\u00edba, Urbanova, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regiane","family":"Albertini","sequence":"additional","affiliation":[{"name":"Research Group of Laser and Inflammation, Instituto de Pesquisa & Desenvolvimento, Universidade do Valedo Para\u00edba, Urbanova, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Sardinha Leonardo","family":"Lopes","sequence":"additional","affiliation":[{"name":"Research Group of Laser and Inflammation, Instituto de Pesquisa & Desenvolvimento, Universidade do Valedo Para\u00edba, Urbanova, S\u00e3o Jos\u00e9 dos Campos, SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Magnus","family":"Bjordal","sequence":"additional","affiliation":[{"name":"Section of Physiotherapy Science, Institute of Public Health and Primary Health Care, University of Bergen, Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Caire Castro Faria","family":"Neto","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopharmacology, Department of Physiology and Pharmacodynamics, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,8]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2005.23.377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2005.23.377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:22:13Z","timestamp":1777677733000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2005.23.377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1089\/pho.2005.23.377"],"URL":"https:\/\/doi.org\/10.1089\/pho.2005.23.377","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}