{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:18Z","timestamp":1777929018841,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2008,8]]},"abstract":"\n \n Objective:<\/jats:italic>\n <\/jats:bold>\n The aims of the present study were to investigate the effect of low-intensity laser irradiation on the total number of mast cells as well as the percentage of degranulation in human gingiva. Blood vessel dilation was also evaluated.\n \n Background Data:<\/jats:italic>\n <\/jats:bold>\n It has been proposed that low-intensity laser irradiation can ameliorate pain, swelling, and inflammation. In periodontal tissue, mast cells may influence either the destructive events or the defense mechanism against periodontal disease via secretion of cytokines and through cellular migration to improve the healing process. Mast cells play an important role in the inflammatory process.\n \n Methods:<\/jats:italic>\n <\/jats:bold>\n Twenty patients with gingival enlargement indicated for gingivectomy were selected. Gingival fragments were obtained from each patient and divided into three different groups before surgery. One fragment was removed without any irradiation. The two others were submitted to punctual irradiation with an energy density of 8 J\/cm\n 2<\/jats:sup>\n at an output power of 50 mW at 36 Hz for 36 sec before gingivectomy. Nondegranulated and degranulated mast cells were counted in five areas of the gingival fragment connective tissue. Major and minor diameters of the blood vessels were also measured.\n \n Results:<\/jats:italic>\n <\/jats:bold>\n Both red and infrared radiation promoted a significant increase in mast cell degranulation compared to controls; however, no statistically significant differences (\n p<\/jats:italic>\n > 0.05) were observed between the irradiated groups. No significant differences among the groups were observed regarding blood vessel size.\n \n Conclusion:<\/jats:italic>\n <\/jats:bold>\n The results suggests that red and infrared wavelengths promote mast cell degranulation in human gingival tissue, although no dilation of blood vessels was observed. The effects of premature degranulation of mast cells in human tissue and the laser radiation protocol applied in this study encourage further investigations to extend these results into clinical practice.\n <\/jats:p>","DOI":"10.1089\/pho.2007.2140","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T09:34:42Z","timestamp":1216373682000},"page":"315-321","source":"Crossref","is-referenced-by-count":32,"title":["Investigation of Mast Cells in Human Gingiva Following Low-Intensity Laser Irradiation"],"prefix":"10.1177","volume":"26","author":[{"given":"L.B.","family":"Silveira","sequence":"first","affiliation":[{"name":"Professional Master Lasers in Dentistry, IPEN-CNEN\/SP, Cidade Universit\u00e1ria, S\u00e3o Paulo, Brazil."},{"name":"Bioengineering Laboratory, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Prates","sequence":"additional","affiliation":[{"name":"Center for Lasers and Applications, IPEN-CNEN\/SP, Cidade Universit\u00e1ria, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Novelli","sequence":"additional","affiliation":[{"name":"School of Dentistry, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Marigo","sequence":"additional","affiliation":[{"name":"School of Dentistry, Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Garrocho","sequence":"additional","affiliation":[{"name":"School of Dentistry, Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.F.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.R.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pinotti","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratory, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Professional Master Lasers in Dentistry, IPEN-CNEN\/SP, Cidade Universit\u00e1ria, S\u00e3o Paulo, Brazil."},{"name":"Center for Lasers and Applications, IPEN-CNEN\/SP, Cidade Universit\u00e1ria, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:25:57Z","timestamp":1777677957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2007.2140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1089\/pho.2007.2140"],"URL":"https:\/\/doi.org\/10.1089\/pho.2007.2140","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}