{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:36Z","timestamp":1777929036456,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the efficacy of low-level laser therapy (LLLT) for M\u00e9ni\u00e8re's disease (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty patients with unilateral MD were included in the study; all presented with uncontrolled vertigo. The patients were randomly divided into two groups: group 1 patients received LLLT 20 min a day with a 5-mW soft laser for 6 mo, while group 2 received betahistine 16 mg twice a day for 6 mo. According to American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines, the main outcome for vertigo control was considered to be the number of spells per month in the 6 mo before treatment compared with the same parameter in the 6 mo of therapy. The duration of spells expressed in minutes was also considered. Moreover, a hearing test was performed before and after therapy and results were reported as the pure tone average of 500-, 1000-, 2000-, and 3000-Hz frequencies. All results were valued at baseline, and after 3 and 6 mo of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared to baseline, the number and duration of spells were significantly reduced in both groups; statistical significance was detected for the 3-mo control in both groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05 with the multiple pair comparison test). Betahistine seems to have a faster action in spell reduction (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05 comparing the 3-mo results between the two groups). Audiometric examination did not show a statistically significant difference between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our experience, LLLT seems to prevent vertigo spells in MD, although results indicate that it has a slower action than betahistine. Dose-dependent therapeutic effects could explain the last result. In our opinion, increased blood flow in the inner ear is the main mechanism leading to the therapeutic results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/pho.2007.2186","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T08:41:04Z","timestamp":1217320864000},"page":"349-353","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of Low-Level Laser Therapy in M\u00e9ni\u00e8re's Disease: A Pilot Study of 10 Patients"],"prefix":"10.1177","volume":"26","author":[{"given":"R.","family":"Teggi","sequence":"first","affiliation":[{"name":"Ear, Nose, and Throat Department, IRRCS San Raffaele Hospital, Vita-Salute University, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bellini","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, IRRCS San Raffaele Hospital, Vita-Salute University, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fabiano","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, IRRCS San Raffaele Hospital, Vita-Salute University, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bussi","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department, IRRCS San Raffaele Hospital, Vita-Salute University, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:32Z","timestamp":1777677992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2007.2186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1089\/pho.2007.2186"],"URL":"https:\/\/doi.org\/10.1089\/pho.2007.2186","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}