{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:46Z","timestamp":1777929046576,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    Our aim was to analyze the effect of laser phototherapy on the secretory activity of macrophages activated by interferon-\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    (IFN-\n                    <jats:italic toggle=\"yes\">\u03b3<\/jats:italic>\n                    ) and lipopolysaccharide (LPS), and stimulated by substances leached from an epoxy resin\u2013based sealer (AH-Plus) and a calcium hydroxide\u2013based sealer (Sealapex).\n                    <jats:italic toggle=\"yes\">Background Data:<\/jats:italic>\n                    Laser phototherapy can modulate the inflammatory process, improving wound healing. This type of therapy could be useful for modulating postoperative symptoms seen after endodontic treatment.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Cytotoxicity was indirectly assessed by measuring mitochondrial activity. Macrophages were stimulated by the leached substances or not (controls), and the groups were then irradiated or not. The secretion of pro-inflammatory cytokines (TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    and MMP-1) was analyzed using ELISA. Two irradiations at 6-h intervals were done with an As-Ga-Al diode laser (780 nm, 70 mW, spot size 4.0 mm\n                    <jats:sup>2<\/jats:sup>\n                    , 3 J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , for 1.5 sec) in contact mode.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The sealers were non-cytotoxic to macrophages. The production of TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    was significantly decreased by laser phototherapy, regardless of experimental group. The level of secretion of MMP-1 was similar in all groups.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Based on the conditions of this study we concluded that in activated macrophages, laser phototherapy impairs the secretion of the pro-inflammatory cytokine TNF-\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    , but has no influence on MMP-1 secretion.\n                  <\/jats:p>","DOI":"10.1089\/pho.2007.2220","type":"journal-article","created":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T12:26:18Z","timestamp":1233318378000},"page":"37-42","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Laser Phototherapy on the Release of TNF-\n                    <i>\u03b1<\/i>\n                    and MMP-1 by Endodontic Sealer\u2013Stimulated Macrophages"],"prefix":"10.1177","volume":"27","author":[{"given":"Lorena R.","family":"Sousa","sequence":"first","affiliation":[{"name":"Departamento de Dent\u00edstica, Faculdade de Odontologia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno N.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Departamento de Dent\u00edstica, Faculdade de Odontologia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia M.","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Dent\u00edstica, Faculdade de Odontologia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:48Z","timestamp":1777678008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2007.2220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1089\/pho.2007.2220"],"URL":"https:\/\/doi.org\/10.1089\/pho.2007.2220","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}