{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:11:01Z","timestamp":1777929061150,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,2]]},"abstract":"\n Crystalopathies are inflammatory pathologies caused by cellular reactions to the deposition of crystals in the joints. The anti-inflammatory effect of the helium-neon (He-Ne) laser and that of the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, meloxicam, celecoxib, and rofecoxib was studied in acute and chronic arthritis produced by hydroxyapatite and calcium pyrophosphate in rats. The presence of the markers fibrinogen, L-citrulline, nitric oxide, and nitrotyrosine was determined. Crystals were injected into the posterior limb joints of the rats. A dose of 8 J\/cm\n 2<\/jats:sup>\n of energy from an He-Ne laser was applied for 3 d in some groups and for 5 d in other groups. The levels of some of the biomarkers were determined by spectrophotometry, and that of nitrotyrosine was determined by ELISA. For statistical analysis, Fisher's exact test was used, and\n p<\/jats:italic>\n \u00b1 0.05 was considered significant. In arthritic rats, the fibrinogen, L-citrulline, nitric oxide, and nitrotyrosine levels increased in comparison to controls and to the laser-treated arthritic groups (\n p<\/jats:italic>\n \u00b1 0.001), (\n p<\/jats:italic>\n \u00b1 0.001), (\n p<\/jats:italic>\n \u00b1 0.02), and (\n p<\/jats:italic>\n \u00b1 0.01), respectively. When comparing fibrinogen from arthritic rats with disease induced by hydroxyapatite with undiseased and arthritic rats treated with NSAIDs, the He-Ne laser decreased levels to values similar to those seen in controls (\n p<\/jats:italic>\n \u00b1 0.01). Inflammatory and oxidative stress markers in experimental crystalopathy are positively modified by photobiostimulation.\n <\/jats:p>","DOI":"10.1089\/pho.2007.2232","type":"journal-article","created":{"date-parts":[[2009,2,15]],"date-time":"2009-02-15T04:22:06Z","timestamp":1234671726000},"page":"79-84","source":"Crossref","is-referenced-by-count":11,"title":["Inflammatory and Oxidative Stress Markers in Experimental Crystalopathy: Their Modification by Photostimulation"],"prefix":"10.1177","volume":"27","author":[{"given":"Claudia Reinoso","family":"Rubio","sequence":"first","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Capital, C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Simes","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Capital, C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Moya","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Capital, C\u00f3rdoba"},{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Carrera de Medicina, Universidad Nacional de La Rioja, Vicente Bustos y Ren\u00e9 Favaloro, Capital, C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Soriano","sequence":"additional","affiliation":[{"name":"Instituto Argentino de Medicina L\u00e1ser, Rosario, Santa Fe, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Atilio","family":"Palma","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Capital, C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Campana","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Capital, C\u00f3rdoba"},{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Carrera de Medicina, Universidad Nacional de La Rioja, Vicente Bustos y Ren\u00e9 Favaloro, Capital, C\u00f3rdoba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2007.2232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:26:55Z","timestamp":1777678015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2007.2232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1089\/pho.2007.2232"],"URL":"https:\/\/doi.org\/10.1089\/pho.2007.2232","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}