{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:10:33Z","timestamp":1777929033508,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,8]]},"abstract":"\n \n Objective:<\/jats:italic>\n <\/jats:bold>\n The aim of this work was to investigate the capacity of low-level laser therapy (LLLT) alone or in combination with antivenom (AV) to reduce myonecrosis induced by\n Bothrops jararacussu<\/jats:italic>\n snake venom.\n \n Background Data:<\/jats:italic>\n <\/jats:bold>\n Myonecrosis is the most pronounced local effect caused by\n B. jararacussu<\/jats:italic>\n venom. AV therapy and other first-aid treatments do not reverse these local effects.\n \n Material and Methods:<\/jats:italic>\n <\/jats:bold>\n Male Swiss mice were used. Myonecrosis was induced by injection of 0.6\u2009mg\/kg of\n B. jararacussu<\/jats:italic>\n venom in the right gastrocnemius muscle and was evaluated at 3 or 24\u2009h after venom injection. The site of venom administration was irradiated for 29\u2009s with a low power semiconductor laser (685\u2009nm) at a dose of 4.2\u2009J\/cm\n 2<\/jats:sup>\n . Intravenous AV therapy (0.5\u2009mL dose) was administered at different times: 30\u2009min before venom injection or 0, 1, or 3\u2009h afterward. Both AV therapy and LLLT treatments were duplicated in mice groups killed at 3 or 24\u2009h.\n \n Results:<\/jats:italic>\n <\/jats:bold>\n B. jararacussu<\/jats:italic>\n venom caused a significant myonecrotic effect 3 and 24\u2009h after venom injection. LLLT significantly reduced myonecrosis by 83.5% at 24\u2009h (\n p<\/jats:italic>\n \u2009<\u20090.05) but not at 3\u2009h, and AV therapy alone was ineffective for reducing myonecrosis at 3 and 24\u2009h.\n \n Conclusion:<\/jats:italic>\n <\/jats:bold>\n Only LLLT significantly reduced myonecrosis of the envenomed muscle, suggesting that LLLT is a potentially therapeutic approach for treating the local effects of\n B. jararacussu<\/jats:italic>\n venom.\n <\/jats:p>","DOI":"10.1089\/pho.2008.2296","type":"journal-article","created":{"date-parts":[[2009,6,16]],"date-time":"2009-06-16T09:27:25Z","timestamp":1245144445000},"page":"591-597","source":"Crossref","is-referenced-by-count":34,"title":["Effect of Low-Level Laser Therapy in the Myonecrosis Induced by\n Bothrops jararacussu<\/i>\n Snake Venom"],"prefix":"10.1177","volume":"27","author":[{"given":"Ana Maria","family":"Barbosa","sequence":"first","affiliation":[{"name":"University of Vale do Para\u00edba (UNIVAP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Balbin","family":"Villaverde","sequence":"additional","affiliation":[{"name":"University Camilo Castelo Branco (UNICASTELO)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila Guimar\u00e3es","family":"Sousa","sequence":"additional","affiliation":[{"name":"University of Vale do Para\u00edba (UNIVAP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egberto","family":"Munin","sequence":"additional","affiliation":[{"name":"University Camilo Castelo Branco (UNICASTELO)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Maria","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Butantan Institute","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Cogo","sequence":"additional","affiliation":[{"name":"University of Vale do Para\u00edba","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella Regina","family":"Zamuner","sequence":"additional","affiliation":[{"name":"University of Campinas (UNICAMP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2008.2296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2008.2296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:27:46Z","timestamp":1777678066000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/pho.2008.2296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1089\/pho.2008.2296"],"URL":"https:\/\/doi.org\/10.1089\/pho.2008.2296","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}