{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:13Z","timestamp":1777929133802,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    To evaluate the efficacy of photodynamic therapy (PDT) against methicillin resistant-\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) by selecting different light sources for irradiation and combining them with the photosensitizer Na-Pheophorbide a (Na-Phde a).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    The treatment of drug-resistant bacterial infection is a serious issue. Recently, as a new clinical approach against septic arthritis, an experimental\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    model for the inactivation of MRSA by PDT using the photosensitizer Na-Phde a has been developed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Na-Phde a solution (280\u2009\u03bcmol\/L) was mixed with MRSA strain bacterial inoculum. After 60 minutes, light was irradiated for 30 minutes using the following light sources: GaA1p semiconductor laser (300\u2009mW, 670nm), halogen lamp (75\u2009W), xenon lamp (300\u2009W) and fluorescent lamp (27\u2009W). Bacterial growth was evaluated after 24 hours incubation in a blood agar culture.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The semiconductor laser and halogen lamp groups showed perfect bactericidal effects after PDT. The xenon lamp and fluorescent lamp groups showed partial bactericidal effects.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The results of this experiment showed that PDT using the combination of Na-Phde a with a semiconductor laser or halogen lamp showed a better bactericidal performance than with xenon or fluorescent lamps. These findings indicated that PDT using Na-Phde a could be a useful treatment for septic arthritis and soft tissue infection.\n                  <\/jats:p>","DOI":"10.1089\/pho.2008.2319","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T17:55:49Z","timestamp":1251482149000},"page":"849-853","source":"Crossref","is-referenced-by-count":16,"title":["Bactericidal Effect of Photodynamic Therapy Using Na-Pheophorbide a: Evaluation of Adequate Light Source"],"prefix":"10.1177","volume":"27","author":[{"given":"Toru","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Iriuchishima","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsumasa","family":"Okano","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunsei","family":"Goto","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Nagai","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Horaguchi","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnosuke","family":"Ryu","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.527-544.2002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/bmj.307.6911.1049","article-title":"Diagnosis and management of methicillin resistant Staphylococcus aureus infection","volume":"307","author":"Duckworth G.J.","year":"1993","unstructured":"Duckworth G.J. 1993. 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