{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:30Z","timestamp":1777929150092,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The effects of UVA irradiation on sites of Q-switched ruby laser (QRL) irradiation were grossly and histopathologically investigated, using UVB-induced spotty pigmentation in the skin of a hairless dog.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background Data:<\/jats:italic>\n                    <\/jats:bold>\n                    There is no experimental evidence to date that UV irradiation stimulates melanocytes and melanogenesis in skin treated with QRL irradiation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    The spotty pigmentation in the skin of the hairless dog was treated with QRL irradiation. The deleterious effects of UVA irradiation on the QRL-treated sites were then examined.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Two weeks after the completion of UVA irradiation, pigmentation began from the surroundings of the QRL-treated sites and\/or the remaining hair follicles. Pigmentation became more prominent and the recurrence of hyperpigmentation more frequent. Histopathologically, 1\u2009wk after QRL irradiation, there were some vacuolated dihydroxyphenylalanine (DOPA)-positive melanocytes in which melanin granules were completely destroyed. At the QRL\u2009+\u2009UVA\u2013treated sites, the number of DOPA-positive melanocytes increased significantly from 2\u2009wk, peaking at 4 to 6\u2009wk after completion of UVA irradiation. From 6\u2009wk after UVA irradiation, there was a return to a normal distribution of DOPA-positive melanocytes. In areas of recurrence of hyperpigmentation, melanin granules aggregated at the bottom of the nucleus of each epidermal cell. The lower portions of hair follicles produced an excess of melanin granules.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    UVA irradiation had deleterious effects on the QRL-treated sites and caused a recurrence of spotty pigmentation. Hairless dogs are useful laboratory animals for evaluating gross and histopathological changes in pigmented lesions treated with QRL irradiation.\n                  <\/jats:p>","DOI":"10.1089\/pho.2008.2344","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T09:53:47Z","timestamp":1251366827000},"page":"749-755","source":"Crossref","is-referenced-by-count":1,"title":["The Effects of UVA Irradiation on Depigmented Sites in the Skin of the Hairless Dog"],"prefix":"10.1177","volume":"27","author":[{"given":"Tohru","family":"Kimura","sequence":"first","affiliation":[{"name":"National Institutes of Natural Sciences","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_3_2_3_2","first-page":"680","article-title":"Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation","volume":"49","author":"Murphy G.F.","year":"1983","unstructured":"Murphy G.F., , Shepard R.S., , Paul B.S., , Menkes A., , Anderson R.R., , Parrish J.A. 1983. 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