{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:12:18Z","timestamp":1777929138106,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objectives:<\/jats:italic>\n                    <\/jats:bold>\n                    To evaluate the effect of laser irradiation (LI) on the glycemic state and the histological and ionic parameters of the parotid and submandibular glands in rats with diabetes.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    One hundred twenty female rats were divided into eight groups. Diabetes was induced by administration of streptozotocin and confirmed later according to results of glycemia testing. Twenty-nine days after the induction, the parotid and submandibular glands of the rats were irradiated with 5, 10, and 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    using a laser diode (660\u2009nm\/100\u2009mW) (without diabetes: C5, C10, and C20; with diabetes: D5, D10, and D20, respectively). On the following day, the rats were euthanized, and blood glucose determined. Histological and ionic analyses were performed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Rats with diabetes without irradiation (D0) showed lipid droples accumulation in the parotid gland, but accumulation decreased after 5, 10, and 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    of laser irradiation. A decrease in fasting glycemia level from 358.97\u2009\u00b1\u200956.70 to 278.33\u2009\u00b1\u200987.98\u2009mg\/dL for D5 and from 409.50\u2009\u00b1\u2009124.41 to 231.80\u2009\u00b1\u2009120.18\u2009mg\/dL for D20 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) was also observed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    LI should be explored as an auxiliary therapy for control of complications of diabetes because it can alter the carbohydrate and lipid metabolism of rats with diabetes.\n                  <\/jats:p>","DOI":"10.1089\/pho.2008.2452","type":"journal-article","created":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T17:39:30Z","timestamp":1251481170000},"page":"877-883","source":"Crossref","is-referenced-by-count":18,"title":["Ionic and Histological Studies of Salivary Glands in Rats with Diabetes and Their Glycemic State After Laser Irradiation"],"prefix":"10.1177","volume":"27","author":[{"given":"Alyne","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Campos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Nicolau","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02851.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2001.65.10.tb03449.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00088.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.11.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.117815"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01019.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.47.111"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tripleo.2006.11.010","article-title":"Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations","volume":"103","author":"von Bultzingslowen I.","year":"2007","unstructured":"von Bultzingslowen I., , Sollecito T.P., , Fox P.C. et al. 2007. Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 103,Suppl:S57.e1\u201315.","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.2007.S5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(91)90548-Q"},{"key":"e_1_3_3_12_2","first-page":"106","article-title":"The effect of alloxan diabetes upon N-acetylneuraminic acid concentration in the submaxillary glands of rats","volume":"19","author":"Nicolau J.","year":"1969","unstructured":"Nicolau J., , Rosa R., , Fava-de-Moraes F. 1969. The effect of alloxan diabetes upon N-acetylneuraminic acid concentration in the submaxillary glands of rats. Acta Physiol. Lat. Am., 19:106\u201310.","journal-title":"Acta Physiol. Lat. Am."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242006000200004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03168448"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.matbio.2007.05.001","article-title":"Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland","volume":"26","author":"Lamers M.L.","year":"2007","unstructured":"Lamers M.L., , Gimenes F.A., , Nogueira F.N. et al. 2007. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Matrix Biol., 26:572\u201382.","journal-title":"Matrix Biol."},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10103-008-0619-2","article-title":"Effect of diode laser on enzymatics activity of parotid glands of diabetic rats","volume":"24","author":"Simoes A.","year":"2009","unstructured":"Simoes A., , Yamaguchi P.M., , Ganzerla E., , Eduardo C.P, , Nicolau J. 2009. Effect of diode laser on enzymatics activity of parotid glands of diabetic rats. Lasers Med. Sci., 24:591\u20136.","journal-title":"Lasers Med. Sci."},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0305-0491(81)90008-0","article-title":"Effect of alloxan diabetes on rat parotid gland and saliva","volume":"70","author":"Anderson L.C.","year":"1981","unstructured":"Anderson L.C., , Johnson D.A. 1981. Effect of alloxan diabetes on rat parotid gland and saliva. Comp. Biochem. Physiol. B., 70B:725\u201330.","journal-title":"Comp. Biochem. Physiol. B."},{"key":"e_1_3_3_18_2","first-page":"429","article-title":"Effects of streptozotocin-induced diabetes on the rat parotid gland","volume":"51","author":"Hand A.R.","year":"1984","unstructured":"Hand A.R., , Weiss R.E. 1984. Effects of streptozotocin-induced diabetes on the rat parotid gland. Lab. Invest., 51:429\u201340.","journal-title":"Lab. Invest."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000028753.33225.68"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(86)90021-X"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2337\/diacare.22.5.864","article-title":"Plasma magnesium concentration and progression of retinopathy","volume":"22","author":"de Valk H.W.","year":"1999","unstructured":"de Valk H.W., , Hardus P.L., , van Rijn H.J., , Erkelens D.W. 1999. Plasma magnesium concentration and progression of retinopathy. Diabetes Care., 22:864\u20135.","journal-title":"Diabetes Care."},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2337\/diab.35.4.459","article-title":"Magnesium deficiency in IDDM related to level of glycosylated hemoglobin","volume":"35","author":"Sjogren A.","year":"1986","unstructured":"Sjogren A., , Floren C.H., , Nilsson A. 1986. Magnesium deficiency in IDDM related to level of glycosylated hemoglobin. Diabetes, 35:459\u201363.","journal-title":"Diabetes"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.0954-6820.1988.tb19611.x","article-title":"Magnesium, potassium and zinc deficiency in subjects with type II diabetes mellitus","volume":"224","author":"Sjogren A.","year":"1988","unstructured":"Sjogren A., , Floren C.H., , Nilsson A. 1988. Magnesium, potassium and zinc deficiency in subjects with type II diabetes mellitus. Acta Med. Scand., 224:461\u20136.","journal-title":"Acta Med. Scand."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000028748.40917.6f"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1113\/eph8702324","article-title":"Effect of extracellular magnesium on nerve-mediated and acetylcholine-evoked in vitro amylase release in rat parotid gland tissue","volume":"87","author":"Yago M.D.","year":"2002","unstructured":"Yago M.D., , Mata A.D., , Manas M., , Singh J. 2002. Effect of extracellular magnesium on nerve-mediated and acetylcholine-evoked in vitro amylase release in rat parotid gland tissue. Exp. Physiol., 87:321\u20136.","journal-title":"Exp. Physiol."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0135-y"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0548-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00253582","article-title":"Presence of insulin-like immunoreactivity and its biosynthesis in rat and human parotid gland","volume":"22","author":"Murakami K.","year":"1982","unstructured":"Murakami K., , Taniguchi H., , Baba S. 1982. Presence of insulin-like immunoreactivity and its biosynthesis in rat and human parotid gland. Diabetologia, 22:358\u201361.","journal-title":"Diabetologia"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0303-7207(95)03665-T","article-title":"Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland","volume":"115","author":"Tseng C.C.","year":"1995","unstructured":"Tseng C.C., , Boylan M.O., , Jarboe L.A. et al. 1995. Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland. Mol. Cell Endocrinol., 115:13\u20139.","journal-title":"Mol. Cell Endocrinol."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301102"},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2337\/diab.35.7.753","article-title":"Insulin-like material in parotid and submaxillary salivary glands of normal and diabetic adult male mice","volume":"35","author":"Patel D.G.","year":"1986","unstructured":"Patel D.G., , Begum N., , Smith P.H. 1986. Insulin-like material in parotid and submaxillary salivary glands of normal and diabetic adult male mice. Diabetes, 35:753\u20138.","journal-title":"Diabetes"},{"key":"e_1_3_3_32_2","volume-title":"Basic and Clinical Endocrinology","author":"Greenspan F.S.","year":"2004","unstructured":"Greenspan F.S., , Gardner D.G. 2004. Basic and Clinical Endocrinology. New York: McGraw-Hill."},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.1"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/nbt1297-1378","article-title":"The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract","volume":"15","author":"Goldfine I.D.","year":"1997","unstructured":"Goldfine I.D., , German M.S., , Tseng H.C. et al. 1997. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat. Biotechnol., 15:1378\u201382.","journal-title":"Nat. Biotechnol."},{"key":"e_1_3_3_35_2","first-page":"379","article-title":"Effect of ether, sodium pentobarbital and chloral hydrate anesthesia on rat plasma metabolite concentrations","volume":"37","author":"Arola L.","year":"1981","unstructured":"Arola L., , Palou A., , Remesar X., , Herrera E., , Alemany M. 1981. Effect of ether, sodium pentobarbital and chloral hydrate anesthesia on rat plasma metabolite concentrations. Rev. Esp. Fisiol., 37:379\u201386.","journal-title":"Rev. Esp. Fisiol."},{"key":"e_1_3_3_36_2","first-page":"31","article-title":"Salivary gland sexual dimorphism: a brief review","volume":"36","author":"Pinkstaff C.A.","year":"1998","unstructured":"Pinkstaff C.A. 1998. Salivary gland sexual dimorphism: a brief review. Eur. J. Morphol., 36,Suppl:31\u20134.","journal-title":"Eur. J. Morphol."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000117302.73214.1A"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-005-0367-5"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000019876.96703.AE"},{"key":"e_1_3_3_40_2","first-page":"53","article-title":"Molecular mechanism of the therapeutic effect of low-intensity laser radiation","volume":"2","author":"Karu T.","year":"1988","unstructured":"Karu T. 1988. Molecular mechanism of the therapeutic effect of low-intensity laser radiation. Lasers Life Sci., 2:53\u201374.","journal-title":"Lasers Life Sci."},{"key":"e_1_3_3_41_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/1011-1344(95)07281-0","article-title":"Changes in calcium transport in mammalian sperm mitochondria and plasma membrane irradiated at 633\u2009nm (HeNe laser)","volume":"34","author":"Breitbart H.","year":"1996","unstructured":"Breitbart H., , Levinshal T., , Cohen N., , Friedmann H., , Lubart R. 1996. Changes in calcium transport in mammalian sperm mitochondria and plasma membrane irradiated at 633\u2009nm (HeNe laser) J. Photochem. Photobiol. B., 34:117\u201321.","journal-title":"J. Photochem. Photobiol. B."},{"key":"e_1_3_3_42_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/(SICI)1096-9101(1997)21:5<493::AID-LSM12>3.0.CO;2-A","article-title":"Changes in calcium transport in mammalian sperm mitochondria and plasma membranes caused by 780\u2009nm irradiation","volume":"21","author":"Lubart R.","year":"1997","unstructured":"Lubart R., , Friedmann H., , Sinyakov M., , Cohen N., , Breitbart H. 1997. Changes in calcium transport in mammalian sperm mitochondria and plasma membranes caused by 780\u2009nm irradiation. Lasers Surg. Med., 21:493\u20139.","journal-title":"Lasers Surg. Med."},{"key":"e_1_3_3_43_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5978\/islsm.91-OR-03","article-title":"The photobiological basis of low level lasers irradiation therapy","volume":"3","author":"Smith K.","year":"1991","unstructured":"Smith K. 1991. The photobiological basis of low level lasers irradiation therapy. Laser Ther., 3:19\u201324.","journal-title":"Laser Ther."}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2008.2452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2008.2452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2008.2452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:29:15Z","timestamp":1777678155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2008.2452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1089\/pho.2008.2452"],"URL":"https:\/\/doi.org\/10.1089\/pho.2008.2452","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}