{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:25Z","timestamp":1787008225029,"version":"build-2736575974"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to detail the clinical efficacy of low-level laser therapy (LLLT) for the management of bisphosphonate-induced osteonecrosis of the jaws (ONJ-BP).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    ONJ-BP is the correct term, recently emerged, to describe a significant complication in a subset of patients receiving drugs such as zoledronic acid, pamidronate, and alendronate. No definitive standard of care has been set for ONJ-BP and no definitively agreed guidelines have been provided. There is currently no consensus on the correct approach to the issue.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    The investigators studied a prospective cohort of 20 patients affected by ONJ-BP, who received biostimulation with a pulsed diode laser (GaAs). Patients were exposed to a 904-nm infrared laser (50\u2009kHz, 28.4\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    energy density, 40% duty cycle, spot size 0.8\u2009cm). Outcome variables were the size of lesions, edema, visual analogue score of pain, presence of pus, fistulas, and halitosis. Preoperative results were compared with the postoperative outcome and statistically evaluated.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Four weeks after LLLT, a statistically significant difference was observed for reported pain (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0001), clinical size (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0034), edema (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0005), and presence of pus and fistulas (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0078 and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03, respectively).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    This study suggests that LLLT would appear to be a promising modality of treatment for patients with ONJ-BP, providing that clinical efficacy is safe and well tolerated, especially by those patients who require conservative treatment. Of course, this needs to be addressed further in larger and randomly controlled studies in different clinical settings.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2501","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T20:09:42Z","timestamp":1254427782000},"page":"179-184","source":"Crossref","is-referenced-by-count":92,"title":["Effect of Low-Level Laser Irradiation on Bisphosphonate-Induced Osteonecrosis of the Jaws: Preliminary Results of a Prospective Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Matteo","family":"Scoletta","sequence":"first","affiliation":[{"name":"University of Turin","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G.","family":"Arduino","sequence":"additional","affiliation":[{"name":"University of Turin","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Reggio","sequence":"additional","affiliation":[{"name":"University of Turin","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Dalmasso","sequence":"additional","affiliation":[{"name":"University of Turin","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mozzati","sequence":"additional","affiliation":[{"name":"University of Turin","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10103-008-0604-9","article-title":"Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635\u2009nm on open skin wound healing in normal and corticosteroid-treated rats","volume":"24","author":"G\u00e1l P.","year":"2009","unstructured":"G\u00e1l P., , Mokr\u00fd M., , Vidinsk\u00fd B. et al. 2009. 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