{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:14:18Z","timestamp":1777929258781,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    To investigate red fluorescence found in the digestive tract of Wistar rats submitted to stress produced by a liquid diet of 5% glucose and maintenance in darkness.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background Data:<\/jats:italic>\n                    <\/jats:bold>\n                    Protoporphyrin IX (PpIX) is produced by the Harderian gland, located in the inner corner of the eyes of rats. Under stressful conditions this gland increases the production of PpIX, which can be detected in different regions of the body, in a manner reminiscent of a porphyria.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Material and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Sixty-five Wistar rats were used in this study. The fluorescence spectra were registered with optical resolution better than 1.7\u2009nm. The rats were fed a 5% glucose diet, exclusively, up to 120\u2009h. The animals were evaluated throughout the diet period, which included two sequential experiments: considering the red fluorescence of their intestinal tract and the fluorescence that appeared in some external parts of their bodies (paw, tail, nose, and scrotum). The normal diet was reintroduced and new spectra were obtained after 24 and 48\u2009h.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Experiment I showed a marked, time-dependent increase in the intestinal content of porphyrin in rats fed the glucose diet. The fluorescence spectrum of the material identified it as PpIX. The spectra collected in Experiment II showed an increase in fluorescence in the four external areas associated with the duration of the diet. This fluorescence disappeared after reintroduction of the regular diet.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    The feeding of a restricted diet (5% glucose) to Wistar rats resulted in reversible porphyria. Measurement of the fluorescence intensity may be a reliable method for monitoring the porphyrin content of tissues.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2543","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T21:08:20Z","timestamp":1293138500000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Monitoring of Native Fluorescence Induced by a Glucose Diet in Wistar Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Jo\u00e3o W. R.","family":"Hernandez","sequence":"first","affiliation":[{"name":"State University of Campinas (UNICAMP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmyr R.","family":"Reis","sequence":"additional","affiliation":[{"name":"State University of Campinas (UNICAMP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester M.D.","family":"Nicola","sequence":"additional","affiliation":[{"name":"State University of Campinas (UNICAMP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge H.","family":"Nicola","sequence":"additional","affiliation":[{"name":"State University of Campinas (UNICAMP)","place":["Brazil"]},{"name":"Inmetro \u2013 National Institute of Metrology","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2006.24.22"},{"key":"e_1_3_3_3_2","first-page":"779","article-title":"Primi resultati di microspettofluorometria qualitativa del tessuto elastico e collagene","volume":"3","author":"Prenna G.","year":"1964","unstructured":"Prenna G., , Sacchi S. 1964. Primi resultati di microspettofluorometria qualitativa del tessuto elastico e collagene. Bolletino della Societ\u00e0 Medico-Chirurgica di Pavia., 3:779\u2013790.","journal-title":"Bolletino della Societ\u00e0 Medico-Chirurgica di Pavia."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(82)90013-1"},{"key":"e_1_3_3_5_2","first-page":"43","article-title":"Harderian gland of Wistar revised as a protoporphyrin IX producer","volume":"22","author":"Reis E.R.","year":"2005","unstructured":"Reis E.R., , Nicola E.M.D., , Nicola J.H. 2005. Harderian gland of Wistar revised as a protoporphyrin IX producer. Braz. J. Morphol. Sci., 22:43\u201351.","journal-title":"Braz. J. Morphol. Sci."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/03008207409152249","article-title":"Investigations of free and elastin-bound fluorescent substances present in the atherosclerotic lipid and calcium plaques","volume":"2","author":"Banga I.","year":"1974","unstructured":"Banga I., , Bihari-Varga M. 1974. Investigations of free and elastin-bound fluorescent substances present in the atherosclerotic lipid and calcium plaques. Connect. Tissue Res., 2:237\u2013241.","journal-title":"Connect. Tissue Res."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000169507","article-title":"The application of the cytophotometer to study of metabolic transitions of isolated rat heart","volume":"57","author":"Movarec J.","year":"1972","unstructured":"Movarec J., , Hatt P.Y., , Rost F.W.D. 1972. The application of the cytophotometer to study of metabolic transitions of isolated rat heart. Cardiology, 57:61\u201366.","journal-title":"Cardiology"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/184931a0","article-title":"Fluorescence measurements of mitochondrial pyridine nucleotide in aerobiosis and anaerobiosis","volume":"184","author":"Chance B.","year":"1959","unstructured":"Chance B., , Thorell B. 1959. Fluorescence measurements of mitochondrial pyridine nucleotide in aerobiosis and anaerobiosis. Nature, 184:931\u2013934.","journal-title":"Nature"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.1.220325"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/27.1.438504"},{"key":"e_1_3_3_11_2","first-page":"594","article-title":"DNA damage induced by 5-aminolevulinic acid: a possible association with the development of hepatocellular carcinoma in acute intermittent porphyria patients","volume":"25","author":"Onuki J.","year":"2002","unstructured":"Onuki J., , Teixeira P.C., , Medeiros M.H.G., , Di Mascio P. 2002. DNA damage induced by 5-aminolevulinic acid: a possible association with the development of hepatocellular carcinoma in acute intermittent porphyria patients. Qu\u00edm. Nova., 25:594\u2013608.","journal-title":"Qu\u00edm. Nova."},{"key":"e_1_3_3_12_2","unstructured":"Anderson K.E. 2007. Disorders of nutrition and metabolism. Porphyria. Merck Manual. www.msd-brazil.com. 2007 November 15."},{"key":"e_1_3_3_13_2","unstructured":"Jorge S.G. 2007. Porphyrias hepatic. Hepcentro. www.hepcentro.com.br\/porphyria. 2007 December 16."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/cs0580477","article-title":"Identification of two types of porphyria cutanea tarda by measurement of erythrocyte uroporphyrinogen decarboxylase","volume":"58","author":"Elder G.H.","year":"1980","unstructured":"Elder G.H. 1980. Identification of two types of porphyria cutanea tarda by measurement of erythrocyte uroporphyrinogen decarboxylase. Clin. Sci., 58:477\u2013484.","journal-title":"Clin. Sci."},{"key":"e_1_3_3_15_2","first-page":"227","article-title":"Porphyrin metabolism in porphyria cutanea tarda","volume":"14","author":"Elder G.H.","year":"1997","unstructured":"Elder G.H. 1997. Porphyrin metabolism in porphyria cutanea tarda. Semin. Hematol., 14:227\u2013242.","journal-title":"Semin. Hematol."},{"key":"e_1_3_3_16_2","first-page":"91","article-title":"Porphyrias: office procedures and laboratory tests for diagnosis of porphyrin abnormalities","volume":"100","author":"Pathak M.A.","year":"1982","unstructured":"Pathak M.A., , West J.D. 1982. Porphyrias: office procedures and laboratory tests for diagnosis of porphyrin abnormalities. Acta Derm. Venereol. Stockh., 100:91\u2013105.","journal-title":"Acta Derm. Venereol. Stockh."},{"key":"e_1_3_3_17_2","first-page":"17","article-title":"The pathogenesis of acute porphyrias","volume":"22","author":"Prauchner C.A.","year":"2002","unstructured":"Prauchner C.A., , Emanuelli T. 2002. The pathogenesis of acute porphyrias. Rev. HCPA, 22:17\u201325.","journal-title":"Rev. HCPA"},{"key":"e_1_3_3_18_2","first-page":"507","article-title":"Role of heme in endocrine function","volume":"302","author":"Piper W.N.","year":"1988","unstructured":"Piper W.N. 1988. Role of heme in endocrine function. Semin. Hematol., 302:507\u2013508.","journal-title":"Semin. Hematol."},{"key":"e_1_3_3_19_2","first-page":"4","article-title":"In vivo photobleaching detection of endogenous PpIX: experimental study with rat Harderian gland. ASLMS Abstracts","volume":"16","author":"Reis E.R.","year":"2004","unstructured":"Reis E.R., , Nicola E.M.D., , Nicola J.H. 2004. In vivo photobleaching detection of endogenous PpIX: experimental study with rat Harderian gland. ASLMS Abstracts. Lasers Surg. Med. Suppl., 16:4.","journal-title":"Lasers Surg. Med. Suppl."},{"key":"e_1_3_3_20_2","first-page":"841","article-title":"Those red tears: porphyrin and the Norway rat","volume":"30","author":"Harkness J.E.","year":"1980","unstructured":"Harkness J.E., , Ridgway M.D. 1980. Those red tears: porphyrin and the Norway rat. Lab. Anim. Sci., 30:841\u2013844.","journal-title":"Lab. Anim. Sci."},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0009-2797(00)00320-3","article-title":"Porphyric enzymes in hamster harderian gland: a model of damage by porphyrins and their precursors. A chronobiological study on the role of sex differences","volume":"134","author":"Coto-Montes A.","year":"2001","unstructured":"Coto-Montes A., , Boga J.A., , Tom\u00e1s-Zapico C. et al. 2001. Porphyric enzymes in hamster harderian gland: a model of damage by porphyrins and their precursors. A chronobiological study on the role of sex differences. Chem. Biol. Interact., 134:135\u2013149.","journal-title":"Chem. Biol. Interact."},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.bi.12.070143.002233","article-title":"Animal pigments","volume":"12","author":"Rimington C.","year":"1943","unstructured":"Rimington C. 1943. Animal pigments. Ann. Rev. Biochem., 12:425\u2013446.","journal-title":"Ann. Rev. Biochem."},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-079X.1991.tb00456.x","article-title":"Circadian patterns of melatonin, corticosterone and progesterone in male rats subjected chronic stress: effect of constant illumination","volume":"11","author":"Persengiev S.","year":"1991","unstructured":"Persengiev S., , Kanchev L., , Vezenkova G. 1991. Circadian patterns of melatonin, corticosterone and progesterone in male rats subjected chronic stress: effect of constant illumination. J. Pineal Res., 11:57\u201362.","journal-title":"J. Pineal Res."},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/bio.900","article-title":"The influence of light and darkness on cutaneous fluorescence in mice","volume":"21","author":"Juzenas P.","year":"2006","unstructured":"Juzenas P., , Juzeniene A., , Iani V., , Moan J. 2006. The influence of light and darkness on cutaneous fluorescence in mice. Luminescence, 21:59\u2013163.","journal-title":"Luminescence"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/jn\/54.2.257","article-title":"The influence of flavonoid compounds on the nasal excretion of a red pigment by rats subjected to stress conditions","volume":"54","author":"Schereiber M.","year":"1954","unstructured":"Schereiber M., , Elvehjem C.A. 1954. The influence of flavonoid compounds on the nasal excretion of a red pigment by rats subjected to stress conditions. J. Nutr., 54:257\u2013270.","journal-title":"J. Nutr."},{"key":"e_1_3_3_26_2","first-page":"153","article-title":"Non-invasively assessing disturbance and stress in laboratory rats by scoring chromodacryorrhoea","volume":"32","author":"Mason G.","year":"2004","unstructured":"Mason G., , Wilson D., , Hampton C., , W\u00fcrbel H. 2004. Non-invasively assessing disturbance and stress in laboratory rats by scoring chromodacryorrhoea. ATLA, 32:153\u2013159.","journal-title":"ATLA"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1590\/S0102-86502004000200007","article-title":"Altera\u00e7\u00f5es da mucosa intestinal em ratos: estudo morfom\u00e9trico em tr\u00eas diferentes tratamentos ap\u00f3s incuba\u00e7\u00e3o experimental de s\u00e9psis abdominal aguda","volume":"19","author":"Tramonte R.","year":"2004","unstructured":"Tramonte R., , Carvalho R.O.M., , Farias D.C. et al. 2004. Altera\u00e7\u00f5es da mucosa intestinal em ratos: estudo morfom\u00e9trico em tr\u00eas diferentes tratamentos ap\u00f3s incuba\u00e7\u00e3o experimental de s\u00e9psis abdominal aguda. Acta Cirur. Bras., 19:120\u2013125.","journal-title":"Acta Cirur. Bras."},{"key":"e_1_3_3_28_2","first-page":"63","article-title":"The place of screening test and quantitative investigations in the diagnosis of the porphyrias with particular reference to variegate and symptomatic porphyria","volume":"40","author":"Eales L.","year":"1966","unstructured":"Eales L., , Levey M.J., , Sweeney G.D. 1966. The place of screening test and quantitative investigations in the diagnosis of the porphyrias with particular reference to variegate and symptomatic porphyria. S. A. Med. J., 40:63\u201371.","journal-title":"S. A. Med. J."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199804000-00002"},{"key":"e_1_3_3_30_2","first-page":"326","article-title":"Detection of native fluorescence in the gastrointestinal tract according to different diets: experimental studies in Wistar rats. Photomed","volume":"25","author":"Nicola J.H.","year":"2007","unstructured":"Nicola J.H., , Hernandez J.W.R., , Reis E.R., , Mesquita R.C., , Nicola E.M.D. 2007. Detection of native fluorescence in the gastrointestinal tract according to different diets: experimental studies in Wistar rats. Photomed. Laser Surg., 25:326.","journal-title":"Laser Surg."}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2009.2543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2009.2543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2009.2543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:30:09Z","timestamp":1777678209000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2009.2543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1089\/pho.2009.2543"],"URL":"https:\/\/doi.org\/10.1089\/pho.2009.2543","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}