{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:58:23Z","timestamp":1789595903575,"version":"build-2803163510"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to investigate the clinical effects of low-level laser therapy (LLLT) in patients with acute low back pain (LBP) with radiculopathy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background Data:<\/jats:italic>\n                    <\/jats:bold>\n                    Acute LBP with radiculopathy is associated with pain and disability and the important pathogenic role of inflammation. LLLT has shown significant anti-inflammatory effects in many studies.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    A randomized, double-blind, placebo-controlled trial was performed on 546 patients. Group A (182 patients) was treated with nimesulide 200\u2009mg\/day and additionally with active LLLT; group B (182 patients) was treated only with nimesulide; and group C (182 patients) was treated with nimesulide and placebo LLLT. LLLT was applied behind the involved spine segment using a stationary skin-contact method. Patients were treated 5 times weekly, for a total of 15 treatments, with the following parameters: wavelength 904\u2009nm; frequency 5000\u2009Hz; 100-mW average diode power; power density of 20\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    and dose of 3\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ; treatment time 150 sec at whole doses of 12\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . The outcomes were pain intensity measured with a visual analog scale (VAS); lumbar movement, with a modified Schober test; pain disability, with Oswestry disability score; and quality of life, with a 12-item short-form health survey questionnaire (SF-12). Subjects were evaluated before and after treatment. Statistical analyses were done with SPSS 11.5.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Statistically significant differences were found in all outcomes measured (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), but were larger in group A than in B (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0005) and C (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0005). The results in group C were better than in group B (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0005).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The results of this study show better improvement in acute LBP treated with LLLT used as additional therapy.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2576","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T19:59:38Z","timestamp":1260388778000},"page":"553-560","source":"Crossref","is-referenced-by-count":40,"title":["Acute Low Back Pain with Radiculopathy: A Double-Blind, Randomized, Placebo-Controlled Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Ljubica M.","family":"Konstantinovic","sequence":"first","affiliation":[{"name":"Medical School","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko M.","family":"Kanjuh","sequence":"additional","affiliation":[{"name":"Medical School","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andjela N.","family":"Milovanovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milisav R.","family":"Cutovic","sequence":"additional","affiliation":[{"name":"Medical School","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar G.","family":"Djurovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktorija G.","family":"Savic","sequence":"additional","affiliation":[{"name":"Institute for Rheumatology","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra S.","family":"Dragin","sequence":"additional","affiliation":[{"name":"Medical School","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesa D.","family":"Milovanovic","sequence":"additional","affiliation":[{"name":"Medical School","place":["Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22684"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-200006000-00003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJM200102013440508","article-title":"Low back pain","volume":"334","author":"Deyo R.A.","year":"2001","unstructured":"Deyo R.A., , Weinstein J.N. 2001. 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