{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:14:23Z","timestamp":1785392063158,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Tumor depth is the limiting factor for topical photodynamic therapy (PDT) treating cutaneous invasive squamous cell carcinoma (SCC). The thickness of\u2009&lt;\u20092\u20133\u2009mm below the epidermis is the currently recommended effective response depth in nonmelanoma skin cancers. We report an unusual outgrowing SCC with a tumor depth of 5.5\u2009mm, which was successfully treated with PDT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Topical 20% (wt\/wt) 5-aminolaevulinic acid emulsion was applied for 6\u2009h before irradiation with 633-nm red light. The lesion was irradiated 7 times, 1 week apart, at a total dose of 791\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twelve months later, histologic and clinical examination showed a complete remission and no local or systemic metastases. No serious side effects occurred, and the cosmetic outcome was excellent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PDT may offer a noninvasive, well-tolerated, and effective therapy for inoperable low-risk SCC with an outgrowing pattern. It suggests that tumor depth is not an absolute predictor, but only a suggested reference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/pho.2009.2610","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T16:58:53Z","timestamp":1287593933000},"page":"703-706","source":"Crossref","is-referenced-by-count":15,"title":["Clearance of a Thick Invasive Squamous Cell Carcinoma After Multiple Treatments with Topical Photodynamic Therapy"],"prefix":"10.1177","volume":"28","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Fourth Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Ann","family":"Long","sequence":"additional","affiliation":[{"name":"Hokkaido University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ujiie","sequence":"additional","affiliation":[{"name":"Hokkaido University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.1.17"},{"key":"e_1_3_3_3_2","first-page":"1141","article-title":"Evaluation of photodynamic therapy of skin cancers with partial differential alpha-aminolevulinic acid","volume":"115","author":"Xu S.","year":"2002","unstructured":"Xu S., , Wang X., , Xu W., , Xia Y., , Zhang C. 2002. Evaluation of photodynamic therapy of skin cancers with partial differential alpha-aminolevulinic acid. Chin. Med. J. (Engl.), 115:1141\u20131145.","journal-title":"Chin. Med. J. (Engl.)"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1067\/mjd.2002.119649","article-title":"Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study","volume":"47","author":"Szeimies R.M.","year":"2002","unstructured":"Szeimies R.M., , Karrer S., , Radakovic-Fijan S. et al. 2002. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J. Am. Acad. Dermatol., 47:258\u2013262.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2133.2008.08593.x","article-title":"Methylaminolaevulinate-based photodynamic therapy of Bowen's disease and squamous cell carcinoma","volume":"159","author":"Calzavara-Pinton P.G.","year":"2008","unstructured":"Calzavara-Pinton P.G., , Venturini M., , Sala R. et al. 2008. Methylaminolaevulinate-based photodynamic therapy of Bowen's disease and squamous cell carcinoma. Br. J. Dermatol., 159:137\u2013144.","journal-title":"Br. J. Dermatol."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/01.dad.0000245196.73224.cb","article-title":"Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective","volume":"28","author":"Kessler G.M.","year":"2006","unstructured":"Kessler G.M., , Ackerman A.B. 2006. Nomenclature for very superficial squamous cell carcinoma of the skin and of the cervix: a critique in historical perspective. Am. J. Dermatopathol., 28:537\u2013545.","journal-title":"Am. J. Dermatopathol."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04719.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08882.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0190-9622(93)70002-B","article-title":"Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: an alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?","volume":"28","author":"Wolf P.","year":"1993","unstructured":"Wolf P., , Rieger E., , Kerl H. 1993. Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: an alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas? J. Am. Acad. Dermatol., 28:17\u201321.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archderm.134.7.821","article-title":"Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy","volume":"134","author":"Fink-Puches R.","year":"1998","unstructured":"Fink-Puches R., , Soyer H.P., , Hofer A., , Kerl H., , Wolf P. 1998. Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy. Arch. Dermatol., 134:821\u2013826.","journal-title":"Arch. Dermatol."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.07.017"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.0906-6705.2004.00181.x","article-title":"Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study","volume":"13","author":"Ahmadi S.","year":"2004","unstructured":"Ahmadi S., , McCarron P.A., , Donnelly R.F., , Woolfson A.D., , McKenna K. 2004. Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study. Exp. Dermatol., 13:445\u2013451.","journal-title":"Exp. Dermatol."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.118012"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jaad.2005.02.059","article-title":"Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia, I: experience over 10 years","volume":"53","author":"Leibovitch I.","year":"2005","unstructured":"Leibovitch I., , Huilgol S.C., , Selva D., , Hill D., , Richards S., , Paver R. 2005. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia, I: experience over 10 years. J. Am. Acad. Dermatol., 53:253\u2013260.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.10.1247"},{"key":"e_1_3_3_16_2","first-page":"284","article-title":"Topical use of 5-fluorouracil cream for skin cancer","volume":"3","author":"Ryan R.F.","year":"1971","unstructured":"Ryan R.F., , Litwin M.S., , Reed R.J. 1971. Topical use of 5-fluorouracil cream for skin cancer. Mod. Trends Surg., 3:284\u2013296.","journal-title":"Mod. Trends Surg."},{"issue":"24","key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/0190-9622(91)70160-4","article-title":"The five-year cure rate achieved by cryosurgery for skin cancer","volume":"1","author":"Kuflik E.G.","year":"1991","unstructured":"Kuflik E.G., , Gage A.A. 1991. The five-year cure rate achieved by cryosurgery for skin cancer. J. Am. Acad. Dermatol., 1,24:1002\u20131004.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-4362.1995.tb04382.x","article-title":"Interferon reduces recurrences of basal cell and squamous cell cancers","volume":"34","author":"Ikic D.","year":"1995","unstructured":"Ikic D., , Padovan I., , Pipic N. et al. 1995. Interferon reduces recurrences of basal cell and squamous cell cancers. Int. J. Dermatol., 34:58\u201360.","journal-title":"Int. J. Dermatol."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2007.01441.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.2.248"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-004-0314-x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0781.2008.00345.x","article-title":"Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomes","volume":"24","author":"Kyriazi M.","year":"2008","unstructured":"Kyriazi M., , Alexandratou E., , Yova D., , Rallis M., , Trebst T. 2008. Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomes. Photodermatol. Photoimmunol. Photomed., 24:87\u201394.","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2133.1999.02991.x","article-title":"Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion","volume":"141","author":"Henta T.","year":"1999","unstructured":"Henta T., , Itoh Y., , Kobayashi M., , Ninomiya Y., , Ishibashi A. 1999. Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. Br. J. Dermatol., 141:347\u2013349.","journal-title":"Br. J. Dermatol."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00516-t1.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/gut.47.5.612","article-title":"Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial","volume":"47","author":"Ackroyd R.","year":"2000","unstructured":"Ackroyd R., , Brown N.J., , Davis M.F. et al. 2000. Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial. Gut, 47:612\u2013617.","journal-title":"Gut"},{"key":"e_1_3_3_26_2","first-page":"1785","article-title":"Cold-knife conization versus photodynamic therapy with topical 5-aminolevulinic acid (5-ALA) in cervical intraepithelial neoplasia (CIN) II with associated human papillomavirus infection: a comparison of preliminary results","volume":"23","author":"Bodner K.","year":"2003","unstructured":"Bodner K., , Bodner-Adler B., , Wierrani F. et al. 2003. Cold-knife conization versus photodynamic therapy with topical 5-aminolevulinic acid (5-ALA) in cervical intraepithelial neoplasia (CIN) II with associated human papillomavirus infection: a comparison of preliminary results. Anticancer Res., 23:1785\u20131788.","journal-title":"Anticancer Res."},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s002400000162","article-title":"Effect of photodynamic therapy on urinary bladder function: an experimental study with rats","volume":"29","author":"Gronlund-Pakkanen S.","year":"2001","unstructured":"Gronlund-Pakkanen S., , Pakkanen T.M., , Koski E., , Talja M., , Ala-Opas M., , Alhava E. 2001. Effect of photodynamic therapy on urinary bladder function: an experimental study with rats. Urol. Res., 29:205\u2013209.","journal-title":"Urol. Res."},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30331.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2340\/00015555-0623","article-title":"Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease","volume":"89","author":"Fukui T.","year":"2009","unstructured":"Fukui T., , Watanabe D., , Tamada Y., , Matsumoto Y. 2009. Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease. Acta Derm. Venereol., 89:150\u2013154.","journal-title":"Acta Derm. Venereol."},{"key":"e_1_3_3_30_2","first-page":"63","article-title":"Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study","volume":"30","author":"Pagliaro J.","year":"2004","unstructured":"Pagliaro J., , Elliott T., , Bulsara M., , King C., , Vinciullo C. 2004. Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study. Dermatol. Surg., 30:63\u201366.","journal-title":"Dermatol. Surg."},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2133.2007.07959.x","article-title":"Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial","volume":"157","author":"Babilas P.","year":"2007","unstructured":"Babilas P., , Knobler R., , Hummel S. et al. 2007. Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. Br. J. Dermatol., 157:111\u2013117.","journal-title":"Br. J. Dermatol."}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2009.2610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2009.2610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2009.2610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:30:39Z","timestamp":1777678239000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2009.2610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1089\/pho.2009.2610"],"URL":"https:\/\/doi.org\/10.1089\/pho.2009.2610","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}