{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:05Z","timestamp":1777929185666,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    Heat-shock proteins (HSPs) are indicative of stressing conditions that may affect cell viability. In\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    , acid stress induces high levels of GroEL, an HSP, in addition to metabolic alterations, as shown by proteomic analysis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    We tested whether the expression of GroEL by\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    was enhanced after photodynamic therapy (PDT) with rose bengal.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    was grown in complete medium supplemented with 50\u2009mmol\/L glucose. The test conditions used were as follows: Rose bengal (0.1\u2009\u03bcmol\/L) with and without light treatment (500\u2009mJ\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), light treatment alone, and 1\u2009mol\/L NaCl (as a stress condition). The extracellular pH of bacteria was monitored; HSP expression was assayed with Western blot, and possible DNA damage analyzed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Higher HSP expression was detected in bacteria after PDT treatment as compared with light or dye alone (negative controls). The expression of HSP after PDT was similar to that induced by osmotic stress. No DNA degradation was observed after PDT of\n                    <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                    .\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    PDT may cause effects similar to those of other stressing conditions in\n                    <jats:italic toggle=\"yes\">S. mutans,<\/jats:italic>\n                    and cell death induced by this treatment reflects its incapacity to protect itself sufficiently against the deleterious effects of PDT with Rose bengal.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2635","type":"journal-article","created":{"date-parts":[[2010,7,22]],"date-time":"2010-07-22T15:37:14Z","timestamp":1279813034000},"source":"Crossref","is-referenced-by-count":25,"title":["Photodynamic Therapy with Rose Bengal Induces GroEL Expression in\n                    <i>Streptococcus mutans<\/i>"],"prefix":"10.1177","volume":"28","author":[{"given":"Mayte","family":"Bolean","sequence":"first","affiliation":[{"name":"Faculdade de Filosofia Ci\u00eancias e Letras de Ribeir\u00e3o Preto","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony de Paiva","family":"Paulino","sequence":"additional","affiliation":[{"name":"Universidade Federal do Triangulo Mineiro-UFTM\/CEFORES","place":["Brasil"]},{"name":"Universidade de Uberaba","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Geraldo","family":"Thedei","sequence":"additional","affiliation":[{"name":"Universidade de Uberaba","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Ciancaglini","sequence":"additional","affiliation":[{"name":"Faculdade de Filosofia Ci\u00eancias e Letras de Ribeir\u00e3o Preto","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300203"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00030.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.53.2.331-338.1986"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1991.tb00453.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26482-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660060201"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1046\/j.1365-2672.2000.00840.x","article-title":"Role of F1F0-ATPase in the growth of Streptococcus mutans GS5","volume":"88","author":"Suzuki T.","year":"2000","unstructured":"Suzuki T., , Tagami J., , Hanada N. 2000. 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