{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:50:15Z","timestamp":1785894615004,"version":"3.56.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The present study compared the effects of gallium-aluminum-arsenide diode laser and healing oil on fibroblasts, blood vessels, and collagen maturation of skin wounds in Wistar rats.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Twenty-four male rats weighing 325\u2009\u00b1\u200927\u2009g were used. Five wounds, 12\u2009mm in diameter, were made on the animals' backs. The rats were randomly divided into four groups with six animals in each group. Control group: saline solution; L30 group: 30\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    laser; L60 group: 60\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    laser; Oil group: healing oil. Histomorphometric analysis was performed on the scar tissue removed from the different wounds every 4\u2009d for 20\u2009d.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    On day 4, there were significantly more fibroblasts in the wounds treated with the laser and the healing oil compared to the controls. On day 8, there were significantly more fibroblasts in the oil group compared to the L30 and L60 groups. On the same day, the quantity of vessels was significantly greater in the L60 group compared to the other groups. On day 16, there was a significant increase in the number of blood vessels in the wounds treated with the 60\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    laser compared to the other groups. Analysis of the collagen maturation index throughout the experiment showed significantly higher values in the L60 group compared to the other groups at all time points.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    The healing oil exerted a greater effect on fibroblast proliferation, whereas the 60\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    laser was more effective in stimulating angiogenesis and scar-tissue maturation.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2669","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T16:58:53Z","timestamp":1287593933000},"page":"597-602","source":"Crossref","is-referenced-by-count":35,"title":["Comparative Study of the Effects of Gallium-Aluminum-Arsenide Laser Photobiomodulation and Healing Oil on Skin Wounds in Wistar Rats: A Histomorphometric Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Reggiani V.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo D.","family":"Novaes","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio L.P.","family":"Matta","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo P.","family":"Benevides","sequence":"additional","affiliation":[{"name":"Federal University of Ouro Preto","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanciane R.","family":"Faria","sequence":"additional","affiliation":[{"name":"Federal University of Vi\u00e7osa","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V.M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Catholic University of Petropolis","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0006-291X(86)80399-0","article-title":"Demonstration of elevated type I and type III procollagen mRNA levels in cutaneous wounds treated with helium\u2013neon laser","volume":"138","author":"Saperia D.","year":"1986","unstructured":"Saperia D., , Gassberg E., , Lyons R.F. et al. 1986. Demonstration of elevated type I and type III procollagen mRNA levels in cutaneous wounds treated with helium\u2013neon laser. Biochem. Biophys. Res. Commun., 138:1123\u20131128.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/1549541041438623"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2052"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900050105"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1590\/S0102-86502008000300009","article-title":"Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats","volume":"23","author":"Magalh\u00e3es M.S.F.","year":"2008","unstructured":"Magalh\u00e3es M.S.F., , Fechine F.V., , Macedo R.N. et al. 2008. Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats. Acta Cir. Bras., 23:262\u2013269.","journal-title":"Acta Cir. Bras."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/104454704773660930","article-title":"Dose and wavelength of laser light have influence on the repair of cutaneous wounds","volume":"22","author":"Mendez T.M.T.V.","year":"2004","unstructured":"Mendez T.M.T.V., , Pinheiro A.L.B., , Pacheco M.T.T., , Nascimento P.M., , Ramalho L.M.P. 2004. Dose and wavelength of laser light have influence on the repair of cutaneous wounds. J. Clin. Laser Med. Surg., 22:19\u201325.","journal-title":"J. Clin. Laser Med. 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