{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:14:00Z","timestamp":1777929240077,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to evaluate with light microscopy the healing process of third-degree burns on diabetic rats treated with polarized light (\u03bb400\u20132000\u2009nm, 20 or 40\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    \/session, 40\u2009mW\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 2.4\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    \/min, 5.5-cm beam diameter).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    Uncontrolled diabetes mellitus causes severe disruption of the body's metabolism, including healing. Polarized light sources have been shown to be effective in improving healing in many situations.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Animals and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Diabetes mellitus was induced with streptozotocin (60\u2009mg\/kg) in 45 male Wistar albino rats, and a third-degree burn (1.5 by 1.5\u2009cm) was created on the dorsum of each animal under general anesthesia. The animals were randomly distributed into three groups: control, 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , and 40\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . Each group was then divided into three subgroups based on time of death (7, 14, 21\u2009d). Phototherapy (20 or 40\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    per session) was carried out immediately after the burning and repeated daily until the day before death. Following animal death, specimens were removed, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (HE) or Sirius Red or immunomarked with CK AE1\/AE3 antibody. Qualitative and semiquantitative analyses were performed under light microscopy. The results were statistically analyzed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The animals treated with 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    showed significant differences with regard to revascularization and re-epithelialization. Although the 40\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    group showed stimulation of fibroblastic proliferation as an isolated feature, no other difference from the control was observed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Our results suggest that the use of polarized light at 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    effectively improves the healing of third-degree burns on diabetic animals at both early and late stages of repair.\n                  <\/jats:p>","DOI":"10.1089\/pho.2009.2675","type":"journal-article","created":{"date-parts":[[2010,10,20]],"date-time":"2010-10-20T16:58:53Z","timestamp":1287593933000},"page":"613-619","source":"Crossref","is-referenced-by-count":7,"title":["Polarized Light (\u03bb400\u20132000\u2009nm) on Third-Degree Burns in Diabetic Rats: Immunohistochemical Study"],"prefix":"10.1177","volume":"28","author":[{"given":"Priscila Chagas","family":"Oliveira","sequence":"first","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Luiz Barbosa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]},{"name":"S\u00e3o Paulo University","place":["Brazil"]},{"name":"University of Camilo Castelo Branco","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Alves","family":"Reis Junior","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle C.V.","family":"de Castro","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Pimentel","family":"Noia","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyselle C.S.","family":"Meireles","sequence":"additional","affiliation":[{"name":"Southwestern State University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Cangussu","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Maria Pedreira","family":"Ramalho","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo University","place":["Brazil"]},{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.1.69"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/01.PRS.0000041445.76730.23","article-title":"Effects of burn wound excision on bacterial colonization and invasion","volume":"111","author":"Barret J.P.","year":"2003","unstructured":"Barret J.P., , Herndon D.N. 2003. Effects of burn wound excision on bacterial colonization and invasion. Plast. Reconstr. Surg., 111:44\u201350.","journal-title":"Plast. Reconstr. Surg."},{"key":"e_1_3_2_4_2","first-page":"9","article-title":"Primeiro atendimento em queimaduras: a abordagem do dermatologista","volume":"80","author":"Vale E.C.S.D.","year":"2005","unstructured":"Vale E.C.S.D. 2005. Primeiro atendimento em queimaduras: a abordagem do dermatologista. [Initial Care on Burns: a dermatological approach.] An. Bras. Dermatol., 80:9\u201319.","journal-title":"[Initial Care on Burns: a dermatological approach.] An. Bras. Dermatol."},{"key":"e_1_3_2_5_2","first-page":"2228","article-title":"\u00c9valuation et premiers soins d'une br\u00fblure thermique","volume":"52","author":"Wassermann D.","year":"2002","unstructured":"Wassermann D. 2002. \u00c9valuation et premiers soins d'une br\u00fblure thermique. [Assessment and first care of burns.] Rev. 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