{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:27Z","timestamp":1777929327673,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    In this study, we examined the therapeutic effect of photodynamic therapy (PDT) using the photosensitizer Na-Pheophorbide a (Na-Phde a) on osteomyelitis models in rats.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:bold>\n                    Osteomyelitis is one of the most serious infectious problems in the orthopedic field. Recently, as a new clinical approach against septic arthritis, an experimental\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    model for the inactivation of methicillin-resistant-\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    by PDT using Na-Phde a has been developed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Methicillin-sensitive\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MSSA) was injected into the tibia of the rats to create osteomyelitis models (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200910, 10 legs). A total of 560\u2009\u03bcmol\/l of Na-Phde a solution was injected into five of these tibial osteomyelitis models (five legs) 48 h after the initial MSSA infection. Sixty minutes after the Na-Phde a injection, a semiconductor laser (125\u2009mW, 670\u2009nm) was used to irradiate the models for 10 min with a total energy of 93.8\u2009J\/mm\n                    <jats:sup>2<\/jats:sup>\n                    . As a control group, five rats (five legs) were treated with a phosphate buffered saline injection at 48 h after MSSA infection. Weight and leg perimeter changes were plotted. Bacterial growth, histological examination and radiological examination were evaluated at 14 days after initial treatment.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    PDT with Na-Phde a significantly prevented leg swelling. In the PDT group, bone destruction owing to osteomyelitis was inhibited not only histologically but also radiographically.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The results in these experiments show that PDT using Na-Phde a improved osteomyelitis in rats. This suggests that PDT using Na- Phde a can be a useful treatment for osteomyelitis.\n                  <\/jats:p>","DOI":"10.1089\/pho.2010.2803","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T09:58:04Z","timestamp":1293789484000},"page":"183-189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Therapeutic Effect of Photodynamic Therapy Using Na-Pheophorbide a on Osteomyelitis Models in Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Bunsei","family":"Goto","sequence":"first","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Iriuchishima","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Horaguchi","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Tokuhashi","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Nagai","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Harada","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1039\/b507082a","article-title":"Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis","volume":"5","author":"Bisland S.K.","year":"2006","unstructured":"Bisland S.K., , Chien C., , Wilson B.C., , Burch S. 2006. Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis. Photochem. Photobiol. Sci., 5:31\u201338.","journal-title":"Photochem. Photobiol. Sci."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)00076-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.injury.2006.04.009","article-title":"Histology of osteosynthesis associated bone infection","volume":"37","author":"Ochsner P.E.","year":"2006","unstructured":"Ochsner P.E., , Hailemariam S. 2006. Histology of osteosynthesis associated bone infection. 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