{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:00Z","timestamp":1777929300735,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to evaluate the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (PDT) on cervical condylomata accuminate (CA) and to determine the ultrastructural changes of the lesion after treatment.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background Data:<\/jats:italic>\n                    <\/jats:bold>\n                    Although there are many methods to treat cervical CA, a high recurrence rate and cervical scars are troublesome problems.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Forty-eight patients with cervical CA were treated with topical 20% ALA gel followed by PDT through a cylindrical fiber with a wavelength of 630\u2009nm of laser light. The treatment was repeated 7 days later if the lesion had not been removed completely. Eight cases were biopsied before and after treatment, and the biopsied lesions were evaluated by electron microscopy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    After the first PDT treatment, the cervical condylomatous lesions were removed completely in 62.5% (30\/48). The complete response (CR) rate was 95.8% (46\/48) after three treatments. The recurrence rate was 4.4% at the 12-month follow-up. Electron microscopy revealed that ALA-PDT damaged proliferative keratinocytes of CA lesions while the surrounding normal tissue injury was less damaged.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    ALA-PDT is an effective and minimally invasive treatment for cervical CA.\n                  <\/jats:p>","DOI":"10.1089\/pho.2010.2864","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T11:18:24Z","timestamp":1292411904000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Cervical Condylomata Acuminata"],"prefix":"10.1177","volume":"29","author":[{"given":"Mu-Kai","family":"Chen","sequence":"first","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di-Qing","family":"Luo","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Fen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-De","family":"Han","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University","place":["P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,5]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"224","article-title":"Condylomata acuminata of the cervix: histopathology and association with cervical neoplasia","volume":"2","author":"Wilkinson E.J.","year":"1983","unstructured":"Wilkinson E.J., , Nyeem R., , Massey J.K., , Trost D.C. 1983. Condylomata acuminata of the cervix: histopathology and association with cervical neoplasia. Int. J. Gynecol. Pathol., 2:224\u2013225.","journal-title":"Int. J. Gynecol. Pathol."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1080\/00016340701417455","article-title":"Prevalence and genotyping of human papillomavirus infection in women with vulvodynia","volume":"86","author":"Orlandi A.","year":"2007","unstructured":"Orlandi A., , Francesconi A., , Angeloni C. et al. 2007. Prevalence and genotyping of human papillomavirus infection in women with vulvodynia. Acta Obstet. Gynecol. Scand., 86:1003\u20131010.","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1471-0528.2006.01041.x","article-title":"Oral inosiplex in the treatment of cervical condylomata acuminata: a randomised placebo-controlled trial","volume":"113","author":"Georgala S.","year":"2006","unstructured":"Georgala S., , Katoulis A.C., , Befon A., , Georgala C., , Rigopoulos D. 2006. Oral inosiplex in the treatment of cervical condylomata acuminata: a randomised placebo-controlled trial. 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Cancer, 60,8 Suppl:1942\u20131950.","journal-title":"Cancer"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.3.323"},{"issue":"5","key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.2307\/3579816","article-title":"The photobiology of photodynamic therapy: cellular targets and mechanisms","volume":"150","author":"Oleinick N.L.","year":"1998","unstructured":"Oleinick N.L., , Evans H.H. 1998. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat. Res., 150,5 Suppl:S146\u2013156.","journal-title":"Radiat. Res."},{"key":"e_1_3_3_20_2","first-page":"228","article-title":"Photodynamic diagnosis and therapy in gynecology \u2013 current knowledge","volume":"75","author":"Olejek A.","year":"2004","unstructured":"Olejek A., , Rembielak-Stawecka B., , Kozak-Darmas I., , Biniszkiewicz T., , Sieron A. 2004. Photodynamic diagnosis and therapy in gynecology \u2013 current knowledge. Ginekol. 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