{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:00Z","timestamp":1777929300746,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    In this study, we investigate the feasibility of the use of aminolevulinic acid hydrochloride (5-ALA)-induced fluorescence in the detection of parathyroid glands in rats.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    The intraoperative identification of parathyroid glands is difficult, which is one of the main reasons for postoperative hypoparathyroidism.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    An animal experiment was designed. Ten Sprague-Dawley (S-D) adult rats were injected intraperitoneally with a 300\u2009mg\/kg dosage of 5-ALA. Anesthesia and surgical dissection were performed to expose the thyroid gland 1\u2009h later. Blue light with a wavelength of 405\u00b13\u2009nm was used to light the trachea bilaterally in order to detect parathyroid fluorescence by direct vision. Histology of the fluorescent tissue was performed to confirm parathyroid identification.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Parathyroid gland fluorescence was visualized in all 10 S-D rats. The red fluorescence of the parathyroid glands was located on the posterolateral thyroid glands and could be seen with the naked eye. Histology of the fluorescent tissue confirmed the identification of parathyroid glands under light microscopy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    5-ALA induced fluorescence of parathyroid glands can clearly differentiate them from the surrounding tissue by direct vision alone. This method could be used intraoperatively and has potential clinical value.\n                  <\/jats:p>","DOI":"10.1089\/pho.2010.2916","type":"journal-article","created":{"date-parts":[[2011,3,27]],"date-time":"2011-03-27T18:23:12Z","timestamp":1301250192000},"page":"635-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Fluorescence Identification of Parathyroid Glands by Aminolevulinic Acid Hydrochloride in Rats"],"prefix":"10.1177","volume":"29","author":[{"given":"Wei Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu Ming","family":"Guo","sequence":"additional","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An Kui","family":"Yang","sequence":"additional","affiliation":[{"name":"Cancer Center of Sun Yat-sen University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2002.02580.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03435.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480707300819"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160208800352"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1097-0347(199903)21:2<111::AID-HED3>3.0.CO;2-Q","article-title":"Enhanced visualization of parathyroid tissue by infusion of a visible dye conjugated to an antiparathyroid antibody","volume":"21","author":"King R.C.","year":"1999","unstructured":"King R.C., , Mills S.L., , Medina J.E. 1999. Enhanced visualization of parathyroid tissue by infusion of a visible dye conjugated to an antiparathyroid antibody. Head Neck, 21:111\u2013115.","journal-title":"Head Neck"},{"key":"e_1_3_2_7_2","first-page":"1","article-title":"Aminolevulinic acid (Levulan) in photodynamic therapy of actinic keratoses","volume":"6","author":"Lang K.","year":"2001","unstructured":"Lang K., , Schulte K.W., , Ruzicke T., , Fritsch C. 2001. Aminolevulinic acid (Levulan) in photodynamic therapy of actinic keratoses. Skin Therapy Lett., 6:1\u201325.","journal-title":"Skin Therapy Lett."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1470-2045(06)70665-9","article-title":"Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma : a randomised controlled multicentre phase III trial","volume":"7","author":"Stummer W.","year":"2006","unstructured":"Stummer W., , Pichlmeier U., , Meinel T. et al. 2006. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma : a randomised controlled multicentre phase III trial. Lancet., 7:392\u2013401.","journal-title":"Lancet."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0090-4295(94)80167-3","article-title":"Fluorescence photodetection of neoplastic urothelial lesions following intrafescial instillation of 5-aminolevulenic acid","volume":"44","author":"Kriegmair M.","year":"1994","unstructured":"Kriegmair M., , Baumgartner R., , Knuechel R. et al. 1994. Fluorescence photodetection of neoplastic urothelial lesions following intrafescial instillation of 5-aminolevulenic acid. Urology, 44:836\u2013841.","journal-title":"Urology"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1210\/endo.142.11.8594","article-title":"Intraoperative fluorescence visualization of the parathyroid gland in rats","volume":"142","author":"Gahlen J.","year":"2001","unstructured":"Gahlen J., , Winkler S., , Flechtenmacher C., , Prosst R.L., , Herfarth C. 2001. Intraoperative fluorescence visualization of the parathyroid gland in rats. Endocrinology, 142:5031\u20135034.","journal-title":"Endocrinology"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1530\/eje.0.1500743","article-title":"Kinetics of intraoperative fluorescence diagnosis of parathyroid glands","volume":"150","author":"Prosst R.L.","year":"2004","unstructured":"Prosst R.L., , Schroeter L., , Gahlen J. 2004. Kinetics of intraoperative fluorescence diagnosis of parathyroid glands. Eur. J. Endocrinol., 150:743\u2013747.","journal-title":"Eur. J. 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