{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:02:58Z","timestamp":1785312178413,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of this study was to introduce adjunct therapy to intense pulsed light (IPL) and to assess it in terms of safety, expense, feasibility, and efficacy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Currently there is no satisfactory, efficient method for long-term white hair removal.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    We conducted a randomized clinical trial of hirsute patients with excessive white hair on the chin and cheeks. In addition to IPL, the patients were randomly assigned to have their white hair colored with either black eyeliner or black hair dye as an adjunct to IPL aided for of six sessions (with a 4-week interval between sessions). The primary efficacy outcome, which was defined as the outcome after six sessions of therapy, was scored as poor (&lt;30%), fair (30\u201360%) or good (&gt;60%) response to white hair removal in predefined areas. The secondary outcome was recurrence 6 months after the final therapy session.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    In the eyeliner group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =31), 15 (48.4%) individuals showed a fair response, and 16 (51.6%) individuals showed a good response. In the color-dye group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =31), 1 (3.2%), 17 (54.8%) and 13 (41.9%) participants scored poor, fair, and good, respectively. There were no differences in clinician judgment of the treatment success between the eyeliner and color-dye groups after the six therapy sessions (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.895). Thirty-one patients had 6 months of visits (11 in the hair dye and 20 in the eyeliner group). Three participants in the color-dye group and five participants in the eyeliner group failed to show improvement 6 months after the laser surgery. There was no distinguishable pattern of failure between the two study groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =1).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    This study supports that hair coloring is an efficient and feasible technique that can be combined with IPL to eliminate white facial hair.\n                  <\/jats:p>","DOI":"10.1089\/pho.2010.2940","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T17:08:47Z","timestamp":1310144927000},"page":"773-779","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Successful White Hair Removal with Combined Coloring and Intense Pulsed Light (IPL): A Randomized Clinical Trial"],"prefix":"10.1177","volume":"29","author":[{"given":"Robabeh","family":"Alijanpour","sequence":"first","affiliation":[{"name":"Iranian Medical Laser Association","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash Poorsattar","family":"BejehMir","sequence":"additional","affiliation":[{"name":"Babol University of Medical Sciences and Health Services","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Mokmeli","sequence":"additional","affiliation":[{"name":"Iranian Medical Laser Association","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2230.2002.01071.x","article-title":"Laser treatment improves quality of life of hirsute females","volume":"27","author":"Loo W.J.","year":"2002","unstructured":"Loo W.J., , Lanigan S.W. 2002. Laser treatment improves quality of life of hirsute females. Clin. Exp. Dermatol., 27:439\u2013441.","journal-title":"Clin. Exp. Dermatol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06426.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/14764170903449802","article-title":"Unwanted facial hair removal with laser treatment improves quality of life of patients","volume":"12","author":"Maziar A.","year":"2010","unstructured":"Maziar A., , Farsi N., , Mandegarfard M. et al. 2010. Unwanted facial hair removal with laser treatment improves quality of life of patients. J. Cosmet. Laser. Ther., 12:7\u20139.","journal-title":"J. Cosmet. Laser. Ther."},{"key":"e_1_3_2_6_2","first-page":"433","article-title":"Hirsutism","volume":"6","author":"Mofid A.","year":"2008","unstructured":"Mofid A., , Seyyed Alinaghi S.A., , Zandieh S., , Yazdani T. 2008. Hirsutism. Int. J. Clin. Pract., 6:433\u2013443.","journal-title":"Int. J. Clin. Pract."},{"key":"e_1_3_2_7_2","first-page":"7","article-title":"Clinical presentation and etiologic factors of hirsutism in premenopausal Iranian women","volume":"10","author":"Ansarin H.","year":"2007","unstructured":"Ansarin H., , Aziz-Jalali M.H., , Rasi A., , Soltani-Arabshahi R. 2007. Clinical presentation and etiologic factors of hirsutism in premenopausal Iranian women. Arch. Iran. Med., 10:7\u201313.","journal-title":"Arch. Iran. Med."},{"key":"e_1_3_2_8_2","first-page":"242","article-title":"Frequency of hirsutism in medical students in Tehran","volume":"9","author":"Akhiani M.","year":"2006","unstructured":"Akhiani M., , Danesh Pazhouh M., , Barzegari M. et al. 2006. Frequency of hirsutism in medical students in Tehran. Iran. J. Dermatol., 9:242\u2013249.","journal-title":"Iran. J. Dermatol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0140-6736(64)92789-8","article-title":"The prevalence of \u2018Hirsutism\u2019 in young women","volume":"1","author":"Mcnight E.","year":"1964","unstructured":"Mcnight E. 1964. The prevalence of \u2018Hirsutism\u2019 in young women. Lancet, 1:410\u2013413.","journal-title":"Lancet"},{"key":"e_1_3_2_10_2","first-page":"57","article-title":"The association of obesity with infertility and related menstrual abnormalities in woman","volume":"3","author":"Hartz A.J.","year":"1979","unstructured":"Hartz A.J., , Barboriak P.N., , Katayama K.P., , Rimm A.A. 1979. The association of obesity with infertility and related menstrual abnormalities in woman. Int. J. Obes., 3:57\u201373.","journal-title":"Int. J. Obes."},{"key":"e_1_3_2_11_2","first-page":"111","article-title":"The prevalence of hirsutism in adolescent girls in Yazd, Central Iran","volume":"12","author":"Noorbala M.T.","year":"2010","unstructured":"Noorbala M.T., , Kefaie P. 2010. The prevalence of hirsutism in adolescent girls in Yazd, Central Iran. IRCMJ, 12:111\u2013117","journal-title":"IRCMJ"},{"key":"e_1_3_2_12_2","first-page":"278","article-title":"Prevalence of polycystic ovary syndrome in girls aged 14\u201318 years in Isfahan, Iran","volume":"62","author":"Hashemipour M.","year":"2004","unstructured":"Hashemipour M., , Faghihimani S., , Zolfaghary B., , Hovsepian S., , Ahmadi F., , Haghighi S. 2004. Prevalence of polycystic ovary syndrome in girls aged 14\u201318 years in Isfahan, Iran. Horm. Res., 62:278\u2013282.","journal-title":"Horm. 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Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am. J. Pathol., 136:891\u2013897.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000187718","article-title":"Increased insulin sensitivity by metformin enhances intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome","volume":"218","author":"Rezvanian H.","year":"2009","unstructured":"Rezvanian H., , Adibi N., , Siavash M., , Kachuei A., , Shojaee-Moradie F., , Asilian A. 2009. Increased insulin sensitivity by metformin enhances intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome. 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