{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:12Z","timestamp":1777929312804,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Narrow band ultraviolet B (UVB) is an effective and safe option for the treatment of vitiligo. However, a complete and long-lasting repigmention of vitiligo patches is difficult to achieve. Combined treatments with novel sources of phototherapy and topical agents represent possible new strategies.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The purpose of this study was to compare the efficacy of combined tacrolimus and 308-nm excimer light (MEL) vs 308-nm MEL monotherapy in treating vitiligo in a controlled study.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Fifty-three patients affected by vitiligo were enrolled in this open prospective study. Patients were divided into three groups: Group I included 20 patients treated with MEL 308\u2009nm twice weekly and oral vitamin E; Group II included 20 patients treated with MEL 308\u2009nm twice weekly combined with 0.1% tacrolimus once a day and oral vitamin E; and Group III included 13 patients treated only with oral vitamin E. Efficacy was assessed at the end of 12 weeks based on the percentage of repigmentation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Fifty-two patients completed 12 weeks of treatment. Group I (MEL + vitamin E) showed a moderate repigmentation in 35% of patients, good repigmentation in 30%, excellent repigmentation in 25%, and poor repigmentation in 10%; Group II (MEL + tacrolimus 0.1%+ vitamin E) presented moderate repigmentation in 25% of patients, good repigmentation in 40%, excellent repigmentation in 30%, and poor repigmentation in 5%; Group III (vitamin E) showed moderate repigmentation in 16% and 84% did not show signs of repigmentation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Our results demonstrate that the combination treatment of 0.1% tacrolimus ointment plus 308-nm MEL and 308-nm MEL monotherapy are effective, safe, and well tolerated for the treatment of vitiligo compared to treatment with vitamin E. Furthermore, this study suggests that an association with topical immunomodulators could enhance the clinical response in vitiligo, especially in more resistant anatomical sites.\n                  <\/jats:p>","DOI":"10.1089\/pho.2011.3029","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T12:55:05Z","timestamp":1320411305000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":59,"title":["Vitiligo Treatment with Monochromatic Excimer Light and Tacrolimus: Results of an Open Randomized Controlled Study"],"prefix":"10.1177","volume":"30","author":[{"given":"Steven","family":"Nistic\u00f2","sequence":"first","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Chiricozzi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosita","family":"Saraceno","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Schipani","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Chimenti","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000075044","article-title":"Study design and preliminary results from the pilot phase of the PraKtis study: self reported diagnoses of selected skin diseases in a representative sample of the Italian population","volume":"208","author":"Naldi L.","year":"2004","unstructured":"Naldi L., , Colombo P., , Placchesi E.B. et al. 2004. Study design and preliminary results from the pilot phase of the PraKtis study: self reported diagnoses of selected skin diseases in a representative sample of the Italian population. Dermatology, 208:38\u201342.","journal-title":"Dermatology"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/archderm.1977.01640010049006","article-title":"Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark","volume":"113","author":"Howitz J.","year":"1977","unstructured":"Howitz J., , Brodthagen H., , Schwartz M., , Thomsen K. 1977. Prevalence of vitiligo. Epidemiological survey on the Isle of Bornholm, Denmark. Arch. Dermatol., 113:47\u201352.","journal-title":"Arch. Dermatol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08881.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1034\/j.1600-0781.2001.170403.x","article-title":"PUVA and PUVB in vitiligo\u2014are they equally effective?","volume":"17","author":"Mofty M.E.","year":"2001","unstructured":"Mofty M.E., , Zaher H., , Esmat S. et al. 2001. PUVA and PUVB in vitiligo\u2014are they equally effective? Photodermatol. Photoimmunol. Photomed., 17:159\u2013163.","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1067\/mjd.2001.114752","article-title":"Narrow-band ultraviolet B is a useful and well tolerated treatment for vitiligo","volume":"44","author":"Scherschun L.","year":"2001","unstructured":"Scherschun L., , Kim J.J., , Lim H.W. 2001. Narrow-band ultraviolet B is a useful and well tolerated treatment for vitiligo. J. Am. Acad. Dermatol., 44:999\u20131003.","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/09546630252775207","article-title":"Treatment of vitiligo","volume":"13","author":"Taneja A.","year":"2002","unstructured":"Taneja A. 2002. Treatment of vitiligo. J. Dermatolog. Treat., 13:19\u201325.","journal-title":"J. Dermatolog. Treat."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1468-3083.2003.00818.x","article-title":"Monochromatic excimer light 308\u2009nm in the treatment of vitiligo: a pilot study","volume":"17","author":"Leone G.","year":"2003","unstructured":"Leone G., , Iacovelli P., , Parovidolin A., , Picardo M. 2003. Monochromatic excimer light 308\u2009nm in the treatment of vitiligo: a pilot study. J. Eur. Acad. Dermatol. Venereol., 17:531\u2013537.","journal-title":"J. Eur. 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Skin Therapy Lett., 14:5\u20137.","journal-title":"Skin Therapy Lett."},{"key":"e_1_3_2_13_2","first-page":"130","article-title":"Combined excimer laser and topical tacrolimus for the treatment of vitiligo: a pilot study","volume":"30","author":"Kawalek A.Z.","year":"2004","unstructured":"Kawalek A.Z., , Spencer J.M., , Phelps R.G. 2004. Combined excimer laser and topical tacrolimus for the treatment of vitiligo: a pilot study. Dermatol. Surg., 30:130\u2013135.","journal-title":"Dermatol. Surg."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1034\/j.1600-0781.2003.00005.x","article-title":"Repigmentation of chronic vitiligo lesions by following tacrolimus plus ultraviolet-B-narrow band","volume":"19","author":"Castanedo\u2013Cazares J.P.","year":"2003","unstructured":"Castanedo\u2013Cazares J.P., , Lepe V., , Moncada B. 2003. Repigmentation of chronic vitiligo lesions by following tacrolimus plus ultraviolet-B-narrow band. Photodermatol. Photoimmunol. 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Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin. Exp. Dermatol., 32:631\u2013636.","journal-title":"Clin. Exp. Dermatol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0781.2010.00509.x","article-title":"Clinical efficacy of a 308\u2009nm excimer laser in the treatment of vitiligo","volume":"26","author":"Zhang X.Y.","year":"2010","unstructured":"Zhang X.Y., , He Y.L., , Dong J., , Xu J.Z., , Wang J. 2010. Clinical efficacy of a 308\u2009nm excimer laser in the treatment of vitiligo. Photodermatol. Photoimmunol. Photomed., 26:138\u2013142.","journal-title":"Photodermatol. Photoimmunol. 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