{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:48Z","timestamp":1777929408551,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    We aimed to assess histologic changes after the use of laser phototherapy (LPT) during induced tooth movement with 40\u2009g\/F on young adult male rats.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Hyalinization is a sterile necrosis at the pressure zone of the periodontal ligament observed during the initial stages of the orthodontic movement, and extensive hyaline areas might cause an important delay in the tooth movement. The use of LPT is considered an enhancement factor for bone repair, as it stimulates microcirculation as well as the cellular metabolism.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Thirty animals were divided into two groups (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =15), named according to the time of animal death (7, 13, and 19 days). Half of the animals in each group were subjected to irradiation with infrared (IR) laser (\u03bb790\u2009nm, round shaped beam, 40\u2009mW, continuous wave (CW), diameter=2\u2009mm (0.0314\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ), 1.273\u2009W\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , time=2\u00d7112\u2009sec+1\u00d7275\u2009sec (total time 499\u2009sec), 2\u00d7142.6\/4.48\u2009J+1\u00d7350\/11\u2009J, 635.2\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    \/20\u2009J\/ session), during orthodontic movement, the other half were used as nonirradiated controls. After animal death, specimens were sectioned, processed, and stained with hematoxylin and eosin (HE) and Sirius Red, and were used for semi-quantitative histologic analysis by light microscopy. Data were statistically analyzed.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    We demonstrated that LPT positively affected an important aspect of dental movement; the hyalinization. In the present study, we found a significant reduced expression of hyalinization after 19 days. On irradiated subjects, hyalinization was increased at day 7 with significant reduction at day 13.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    It is possible to conclude that the use of laser light caused histologic alterations during the orthodontic movement characterized by increased formation of areas of hyalinization at early stages, and late reduction when compared to nonirradiated animals.\n                  <\/jats:p>","DOI":"10.1089\/pho.2011.3085","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T15:50:25Z","timestamp":1328802625000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Laser Phototherapy on the Hyalinization Following Orthodontic Tooth Movement in Rats"],"prefix":"10.1177","volume":"30","author":[{"given":"Fernando A. 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