{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:17:36Z","timestamp":1777929456585,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    Fluorescence is widely investigated and can characterize general changes occurring in the state of the cell and the tissue during physiological and\/or pathological processes, but the method has not been adopted for clinical use. We present a photodiagnostic device and a relevant evaluation method fitted to classical screening procedures. This method is based on the discovery of smear content intrinsic fluorescent markers.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Meaningful spectral components of cervical smear samples differ from those measured in the entire live cervix. This article deals with the identification of changes in smear spectra in cervicitis and CIN2+ (cervical intraepithelial neoplasia of the second degree or higher) at 355\u2009nm excitation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Methods used in the study: microlaser-induced fluorescence spectroscopy of liquid cytology samples and histological evaluation of the biopsies of the same cervix (and\/or only cytological evaluation) was performed for 78 cases. The fluorescence spectra of cervical cytology supernatant sediment were approximated with several Gaussian components. The ratios of the area under each Gaussian component to the whole area under the experimental curve were calculated and compared among histological groups by using the Mann\u2013Whitney test and receiver operating characteristic (ROC) analysis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The results of this study are a concise summary of the essential features verified by the data: the spectral regions 402\u2013416\u2009nm and 424\u2013438\u2009nm are important for the discrimination of both normal and CIN2+ groups (in terms of sensitivity, specificity, and positive predictive value). The spectral regions 480\u2013515\u2009nm and 595\u2013625\u2009nm are important for the identification of cervicitis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    Cervical smear autofluorescence diagnostics could be useful for cancer screening at the point of care, in a simple cytology laboratory, and for the monitoring of treatment. We suggest possible fluorophores in the smear content.\n                  <\/jats:p>","DOI":"10.1089\/pho.2011.3092","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T14:08:20Z","timestamp":1331734100000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cervical Smear Photodiagnosis by Fluorescence"],"prefix":"10.1177","volume":"30","author":[{"given":"Aurelija","family":"Vaitkuviene","sequence":"first","affiliation":[{"name":"Vilnius University","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilmantas","family":"Gegzna","sequence":"additional","affiliation":[{"name":"Vilnius University","place":["Lithuania"]},{"name":"Vilnius University","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Kurtinaitiene","sequence":"additional","affiliation":[{"name":"Vilnius University Hospital","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juozas V.","family":"Vaitkus","sequence":"additional","affiliation":[{"name":"Vilnius University","place":["Lithuania"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq036"},{"key":"e_1_3_3_3_2","first-page":"51","volume-title":"Selected Papers on Gynaecologic Oncology. 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