{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:21Z","timestamp":1777929381234,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this article is to report a case of bisphosphonate-induced osteonecrosis (ONJ-BP) of the jaw treated by curettage of the necrotic bone, low-level laser therapy (LLLT), and antibiotic therapy.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">data:<\/jats:italic>\n                    <\/jats:bold>\n                    ONJ-BP is characterized by painful ulcerations of the oral mucosa, is prone to bone necrosis that does not heal within 8 weeks after diagnosis, and is often difficult to treat. No definitive standard of care has been established for ONJ-BP. LLLT improves wound healing, relieves pain, and appears to be a promising treatment modality for patients with ONJ-BP.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">and<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">methods:<\/jats:italic>\n                    <\/jats:bold>\n                    An 82-year-old man taking intravenous bisphosphonate presented with ONJ-BP after tooth extraction. The patient was treated by LLLT using a GaAlAs diode laser with the following settings: wavelength, 860\u2009nm; 70\u2009mW; continuous wave; and spot size 4\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    . An energy density of 4.2\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    per point was applied in a punctual contact manner every 48\u2009h for 10 days, in association with antibiotic therapy and curettage of the necrotic bone. Reduction in painful symptoms was reported after the second irradiation session, and tissue healing was complete at the end of the third week following oral curettage. The patient was followed up for 12 months and exhibited good oral healt and quality of life.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The therapeutic protocol used in this study had a positive effect on tissue healing and remission of painful symptoms, resulting in better oral health and quality of life for the patient.\n                  <\/jats:p>","DOI":"10.1089\/pho.2011.3219","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T12:14:27Z","timestamp":1334664867000},"page":"293-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Laser GaAlAs (\u03bb860\u2009nm) Photobiomodulation for the Treatment of Bisphosphonate-Induced Osteonecrosis of the Jaw"],"prefix":"10.1177","volume":"30","author":[{"given":"Milena G\u00f3es","family":"da Guarda","sequence":"first","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gard\u00eania Matos","family":"Paraguass\u00fa","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiadja Santana","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Ramos","family":"Cury","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jener Gon\u00e7alves","family":"Farias","sequence":"additional","affiliation":[{"name":"Metropolitan Union of Culture and Education","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Maria Pedreira","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Federal University of Bahia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0707onj"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.32635\/2176-9745.RBC.2006v52n1.1904","article-title":"Bisfosfonatos e osteonecrose maxilar: revis\u00e3o da literatura e relato de dois casos","volume":"52","author":"Gegler A.","year":"2006","unstructured":"Gegler A., , Cherubini K., , Figueiredo M.A.S., , Yurgel L.S., , Azambuja A.A. 2006. 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