{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:52Z","timestamp":1777929412696,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    the purpose of this study was to investigate the effect of low-level laser therapy (LLLT) on chronic kidney disease (CKD) in a model of unilateral ureteral obstruction (UUO\n                    <jats:italic toggle=\"yes\">).<\/jats:italic>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Regardless of the etiology, CKD involves progressive widespread tissue fibrosis, tubular atrophy, and loss of kidney function. This process also occurs in kidney allograft. At present, effective therapies for this condition are lacking. We investigated the effects of LLLT on the interstitial fibrosis that occurs after experimental UUO in rats.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    The occluded kidney of half of the 32 Wistar rats that underwent UUO received a single intraoperative dose of LLLT (AlGaAs laser, 780\u2009nm, 22.5\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 30\u2009mW, 0.75\u2009W\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , 30\u2009sec on each of nine points). After 14 days, renal fibrosis was assessed by Sirius red staining under polarized light. Immunohistochemical analyses quantitated the renal tissue cells that expressed fibroblast (FSP-1) and myofibroblast (\u03b1-SMA) markers. Reverse transcriptase polymerase chain reaction (RT-PCR) was performed to determine the mRNA expression of interleukin (IL)-6, monocyte chemotactic protein-1 (MCP-1), transforming growth factor (TGF)-\u03b21 and Smad3.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    The UUO and LLLT animals had less fibrosis than the UUO animals, as well having decreased expression inflammatory and pro-fibrotic markers.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic toggle=\"yes\">:<\/jats:italic>\n                    For the first time, we showed that LLLT had a protective effect regarding renal interstitial fibrosis. It is conceivable that by attenuating inflammation, LLLT can prevent tubular activation and transdifferentiation, which are the two processes that mainly drive the renal fibrosis of the UUO model.\n                  <\/jats:p>","DOI":"10.1089\/pho.2012.3272","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T09:21:50Z","timestamp":1352280110000},"page":"705-713","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Low-Level Laser Therapy Decreases Renal Interstitial Fibrosis"],"prefix":"10.1177","volume":"30","author":[{"given":"Fabiana Aparecida Mayrink","family":"Oliveira","sequence":"first","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Meneghin","family":"Moraes","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Povoa","family":"Paiva","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia","family":"Schinzel","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus","family":"Correa-Costa","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo (USP)","place":["Brazil"]},{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Semedo","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00eala","family":"Castoldi","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Antonio","family":"Cenedeze","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Sotto-Maior Fortes","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Gomes","family":"Bastos","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Olsen Saraiva","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo (USP)","place":["Brazil"]},{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helady","family":"Sanders-Pinheiro","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"Federal University of Juiz de Fora","place":["Brazil"]},{"name":"University of S\u00e3o Paulo (USP)","place":["Brazil"]},{"name":"Federal University of S\u00e3o Paulo (UNIFESP)","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000106015.29070.E7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00486.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57582"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1053\/ajkd.2003.50074","article-title":"Progression of chronic renal disease","volume":"41","author":"Klahr S.","year":"2003","unstructured":"Klahr S., , Morrissey J. 2003. 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