{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:52Z","timestamp":1777929412664,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of the present study was to assess the effectiveness of an UVA1 355\u2009nm laser (Alba 355) for treatment of mild, moderate, and severe psoriasis.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    Psoriasis is an immune-inflammatory and proliferative skin disease. During the past few years, the instrumental treatment by UV radiation has been successfully described, either alone or in combination with topical and\/or systemic drug administration to treat several skin-related diseases.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Materials and methods:<\/jats:italic>\n                    <\/jats:bold>\n                    Fourteen patients, aged between 25 and 50 years (37.7\u00b12.3 [mean\u00b1SEM]), affected by mild-to-severe psoriatic plaques, were included in this study. Patients were treated with a new instrument, laser Alba 355, which administers energy in the UVA1 spectrum. This instrument is based on a 1064 wavelength neodymium-doped yttrium orthovanadate (Nd:YVO4) laser optically pumped using a 808\u2009nm infrared beam able to achieve a third harmonic 355\u2009nm wave delivery. The fluences administered were 80\u2013140\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    four times a week for a total of up to 12 sessions over selected psoriatic plaques in different areas of the patients' bodies. The patients rated their satisfaction with the outcome of the procedure as 1 not satisfied, 2 quite satisfied, 3 very satisfied.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    Overall, laser treatment of psoriatic plaques produced a significant improvement in Psoriasis Area and Severity Index (PASI) score (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    [3, 55]=57.86;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001). The mean PASI score decreased from a baseline value of 24.5\u00b12.9 to a value of 15.6\u00b11.9 at 1 week (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001), 9.1\u00b11.2 at 2 weeks (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001), and 5.8\u00b11.2 at 3 weeks (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001). All the patients were very satisfied with the outcome of procedure. No side effects were observed in this study.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:bold>\n                    The present study outlines an original approach based on UVA1 355\u2009nm laser therapy for treatment of mild, moderate, and severe psoriasis. In the present study, the high success rate was coupled with safety. Larger clinical trials are needed to definitely support the role of this medical device not only for treatment of psoriasis, but also for other skin-related diseases that share a similar pathophysiology. We speculate that in the near future, the use of this laser will grow in the dermatology clinic.\n                  <\/jats:p>","DOI":"10.1089\/pho.2012.3281","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T15:22:58Z","timestamp":1344871378000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["A Preliminary Study to Assess the Efficacy of a New UVA1 Laser for Treatment of Psoriasis"],"prefix":"10.1177","volume":"30","author":[{"given":"Nicola","family":"Zerbinati","sequence":"first","affiliation":[{"name":"University of Insubria","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Portale","sequence":"additional","affiliation":[{"name":"University of Insubria","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beniamino","family":"Palmieri","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia Medical School","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Rottigni","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia Medical School","place":["Italy"]},{"name":"Poliambulatorio del Secondo Parere","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Iannitti","sequence":"additional","affiliation":[{"name":"University of Kentucky Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1080-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.10175"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1600-0781.2008.00333.x","article-title":"Narrowband ultraviolet B radiation suppresses contact hypersensitivity","volume":"24","author":"Shintani Y.","year":"2008","unstructured":"Shintani Y., , Yasuda Y., , Kobayashi K., , Maeda A., , Morita A. 2008. Narrowband ultraviolet B radiation suppresses contact hypersensitivity. Photodermatol. Photoimmunol. Photomed., 24:32\u201337.","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-0781.2011.00607.x","article-title":"Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp","volume":"27","author":"Nishida E.","year":"2011","unstructured":"Nishida E., , Furuhashi T., , Kato H., , Kaneko N., , Shintani Y., , Morita A. 2011. Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp. Photodermatol. Photoimmunol. Photomed., 27:248\u2013250.","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05261.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-4632.2009.04427.x","article-title":"UVA1 phototherapy: a review of mechanism and therapeutic application","volume":"49","author":"York N.R.","year":"2010","unstructured":"York N.R., , Jacobe H.T. 2010. UVA1 phototherapy: a review of mechanism and therapeutic application. Int. J. Dermatol., 49:623\u2013630.","journal-title":"Int. J. Dermatol."},{"key":"e_1_3_2_8_2","first-page":"1","article-title":"UVA1 phototherapy: a concise and practical review","volume":"17","author":"Zandi S.","year":"2012","unstructured":"Zandi S., , Kalia S., , Lui H. 2012. UVA1 phototherapy: a concise and practical review. Skin Therapy Lett., 17:1\u20134.","journal-title":"Skin Therapy Lett."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02063.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00474.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/lsm.20590","article-title":"Laser treatments on skin enhancing and controlling transdermal delivery of 5-fluorouracil","volume":"40","author":"Gomez C.","year":"2008","unstructured":"Gomez C., , Costela A., , Garcia\u2013Moreno I., , Llanes F., , Teijon J.M., , Blanco D. 2008. Laser treatments on skin enhancing and controlling transdermal delivery of 5-fluorouracil. Lasers Surg. Med., 40:6\u201312.","journal-title":"Lasers Surg. Med."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2317"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0846.2011.00556.x","article-title":"Targeted 307\u2009nm UVB-phototherapy in psoriasis. A pilot study comparing a 307\u2009nm excimer light with topical dithranol","volume":"18","author":"Wollina U.","year":"2012","unstructured":"Wollina U., , Koch A., , Scheibe A., , Seme B., , Streit I., , Schmidt W.D. 2012. Targeted 307\u2009nm UVB-phototherapy in psoriasis. A pilot study comparing a 307\u2009nm excimer light with topical dithranol. Skin Res. Technol., 18:212\u2013218.","journal-title":"Skin Res. Technol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1468-3083.2008.02942.x","article-title":"308-nm excimer laser in psoriasis vulgaris, scalp psoriasis, and palmoplantar psoriasis","volume":"23","author":"Gattu S.","year":"2009","unstructured":"Gattu S., , Rashid R.M., , Wu J.J. 2009. 308-nm excimer laser in psoriasis vulgaris, scalp psoriasis, and palmoplantar psoriasis. J. Eur. Acad. Dermatol. Venereol., 23:36\u201341.","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"e_1_3_2_16_2","first-page":"505","article-title":"Tacrolimus ointment 0.1% alone and in combination with medium-dose UVA1 in the treatment of palmar or plantar psoriasis","volume":"5","author":"Rivard J.","year":"2006","unstructured":"Rivard J., , Janiga J., , Lim H.W. 2006. Tacrolimus ointment 0.1% alone and in combination with medium-dose UVA1 in the treatment of palmar or plantar psoriasis. Journal of drugs in dermatology. J. Drugs Dermatol., 5:505\u2013510.","journal-title":"Journal of drugs in dermatology. J. Drugs Dermatol."},{"key":"e_1_3_2_17_2","first-page":"169","article-title":"Calcipotriol monotherapy versus calcipotriol plus UVA1 versus calcipotriol plus narrow-band UVB in the treatment of psoriasis","volume":"31","author":"Roussaki\u2013Schulze A.V.","year":"2005","unstructured":"Roussaki\u2013Schulze A.V., , Kouskoukis C., , Klimi E., , Zafiriou E., , Galanos A., , Rallis E. 2005. Calcipotriol monotherapy versus calcipotriol plus UVA1 versus calcipotriol plus narrow-band UVB in the treatment of psoriasis. Drugs Exp. Clin. Res., 31:169\u2013174.","journal-title":"Drugs Exp. Clin. Res."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-0781.2006.00245.x","article-title":"UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States","volume":"22","author":"Tuchinda C.","year":"2006","unstructured":"Tuchinda C., , Kerr H.A., , Taylor C.R. et al. 2006. UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States. Photodermatol. Photoimmunol. Photomed., 22:247\u2013253.","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D318W9J736","article-title":"A Simplified Psoriasis Area Severity Index (SPASI) for rating psoriasis severity in clinic patients","volume":"10","author":"Louden B.A.","year":"2004","unstructured":"Louden B.A., , Pearce D.J., , Lang W., , Feldman S.R. 2004. A Simplified Psoriasis Area Severity Index (SPASI) for rating psoriasis severity in clinic patients. Dermatol. Online J., 10:7.","journal-title":"Dermatol. Online J."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1365-2133.2002.04743.x","article-title":"Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial","volume":"146","author":"Bhushan M.","year":"2002","unstructured":"Bhushan M., , Bleiker T.O., , Ballsdon A.E. et al. 2002. Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial. Br. J. Dermatol., 146:824\u2013831.","journal-title":"Br. J. Dermatol."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJM200107263450403","article-title":"Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes","volume":"345","author":"Ellis C.N.","year":"2001","unstructured":"Ellis C.N., , Krueger G.G. 2001. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. New Engl. J. Med., 345:248\u2013255.","journal-title":"New Engl. J. Med."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02530-7"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.jidsp.5640187","article-title":"Ultraviolet A1 (340\u2013400\u2009nm) irradiation and systemic lupus erythematosus","volume":"4","author":"McGrath H.","year":"1999","unstructured":"McGrath H.Jr. 1999. Ultraviolet A1 (340\u2013400\u2009nm) irradiation and systemic lupus erythematosus. J. Investig. Dermatol. Symp. Proc., 4:79\u201384.","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"e_1_3_2_24_2","first-page":"705","article-title":"Association between UVA1 and PUVA bath therapy and development of malignant melanoma [in German]","volume":"52","author":"Wallenfang K.","year":"2001","unstructured":"Wallenfang K., , Stadler R. 2001. Association between UVA1 and PUVA bath therapy and development of malignant melanoma [in German] Hautarzt, 52:705\u2013707.","journal-title":"Hautarzt"}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2012.3281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2012.3281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2012.3281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:35:00Z","timestamp":1777678500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2012.3281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1089\/pho.2012.3281"],"URL":"https:\/\/doi.org\/10.1089\/pho.2012.3281","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}