{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:04:00Z","timestamp":1782057840167,"version":"3.54.5"},"reference-count":5,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2014,3]]},"abstract":"\n \n Objective:<\/jats:italic>\n <\/jats:bold>\n This case report describes the effects of low-level laser therapy (LLLT) in a single patient with retinitis pigmentosa (RP).\n \n Background data:<\/jats:italic>\n <\/jats:bold>\n RP is a heritable disorder of the retina, which eventually leads to blindness. No therapy is currently available.\n \n Methods:<\/jats:italic>\n <\/jats:bold>\n LLLT was applied using a continuous wave laser diode (780\u2009nm, 10\u2009mW average output at 292\u2009Hz, 50% pulse modulation). The complete retina of eyes was irradiated through the conjunctiva for 40\u2009sec (0.4\u2009J, 0.333\u2009W\/cm\n 2<\/jats:sup>\n ) two times per week for 2 weeks (1.6\u2009J). A 55-year-old male patient with advanced RP was treated and followed for 7 years.\n \n Results:<\/jats:italic>\n <\/jats:bold>\n The patient had complained of nyctalopia and decreasing vision. At first presentation, best visual acuity was 20\/50 in each eye. Visual fields were reduced to a central residual of 5 degrees. Tritan-dyschromatopsy was found. Retinal potential was absent in electroretinography. Biomicroscopy showed optic nerve atrophy, and narrow retinal vessels with a typical pattern of retinal pigmentation. After four initial treatments of LLLT, visual acuity increased to 20\/20 in each eye. Visual fields normalized except for a mid-peripheral absolute concentric scotoma. Five years after discontinuation of LLLT, a relapse was observed. LLLT was repeated (another four treatments) and restored the initial success. During the next 2 years, 17 additional treatments were performed on an \u201cas needed\u201d basis, to maintain the result.\n \n Conclusions:<\/jats:italic>\n <\/jats:bold>\n LLLT was shown to improve and maintain vision in a patient with RP, and may thereby have contributed to slowing down blindness.\n <\/jats:p>","DOI":"10.1089\/pho.2013.3535","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T15:48:57Z","timestamp":1392392937000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Low-Level Laser Therapy Improves Vision in a Patient with Retinitis Pigmentosa"],"prefix":"10.1177","volume":"32","author":[{"given":"Boris T.","family":"Ivandic","sequence":"first","affiliation":[{"name":"University of Heidelberg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomislav","family":"Ivandic","sequence":"additional","affiliation":[{"name":"Medical Center","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"175","article-title":"Histopathology of the human retina in retinitis pigmentosa","volume":"17","author":"Miliam A.H.","year":"1998","unstructured":"Miliam A.H., , Li Z.Y., , and Fariss R.N. (1998). Histopathology of the human retina in retinitis pigmentosa. Prog. Retin. Eye Res., 17, 175\u2013205.","journal-title":"Prog. Retin. Eye Res."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(02)00332-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1076\/ceyr.24.1.26.5432","article-title":"Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents","volume":"24","author":"An G.J.","year":"2002","unstructured":"An G.J., , Asayama N., , Humayun M.S., et al. (2002). Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents. Curr. Eye Res., 24, 26\u201332.","journal-title":"Curr. Eye Res."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2132"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3089"}],"container-title":["Photomedicine and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/pho.2013.3535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2013.3535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/pho.2013.3535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:36:49Z","timestamp":1777678609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/pho.2013.3535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1089\/pho.2013.3535"],"URL":"https:\/\/doi.org\/10.1089\/pho.2013.3535","relation":{},"ISSN":["1549-5418","1557-8550"],"issn-type":[{"value":"1549-5418","type":"print"},{"value":"1557-8550","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}