{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:19:39Z","timestamp":1790648379620,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photomedicine and Laser Surgery"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    <\/jats:bold>\n                    The present study was conducted to investigate the effects of helium-neon (He-Ne) laser irradiation on the proliferation, migration, and differentiation of cultured human epidermal stem cells (ESCs).\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Background data:<\/jats:italic>\n                    <\/jats:bold>\n                    A He-Ne laser with a wavelength of 632.8\u2009nm is known to have photobiological effects, and is widely used for accelerating wound healing; however, the cellular mechanisms involved have not been completely understood.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:bold>\n                    The ESCs were prepared from human foreskin, and irradiated by using He-Ne laser at 632.8\u2009nm with 2\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . The ESC proliferation, migration, and differentiation were examined by using XTT assay, scratch assay, and flow cytometry technology, respectively. The phosphorylation of extracellular signal-regulated kinases (ERK) was analyzed by using Western blotting.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:bold>\n                    He-Ne laser irradiation markedly promoted cell proliferation and migration accompanied by an increase in the phosphorylation of ERK, but did not significantly influence cell differentiation.\n                    <jats:bold>\n                      <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    <\/jats:bold>\n                    Our data indicated that photostimulation with a He-Ne laser resulted in a significant increase in human ESC proliferation and migration\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , which might contribute, at least partially, to accelerated wound re-epithelialization by low-level laser therapy.\n                  <\/jats:p>","DOI":"10.1089\/pho.2013.3667","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T12:28:53Z","timestamp":1395664133000},"page":"219-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Helium-Neon Laser Irradiation Promotes the Proliferation and Migration of Human Epidermal Stem Cells\n                    <i>In Vitro<\/i>\n                    : Proposed Mechanism for Enhanced Wound Re-epithelialization"],"prefix":"10.1177","volume":"32","author":[{"given":"Xuan","family":"Liao","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Jinan University","place":["P.R. 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xie","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ling","family":"Xiao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bing","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute for Basic Research","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,4]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"45","article-title":"Effects of low-level helium-neon laser on induced wound healing in rats","volume":"14","author":"Busnardo V.L.","year":"2010","unstructured":"Busnardo V.L., , and Biondo-Sim\u00f5es M.L. (2010). 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